Research Progress Of Collagen In Pancreatic Cancerresearch Progress Of Collagen In Pancreatic Cancer
Keywords
Collagen, Pancreatic Cancercollagen, Pancreatic Cancer
Abstract
Collagen is a large family of triple-helical proteins widely distributed throughout the body. It is a triple-helix structure composed of three ¦Á-peptide chains. They can be divided into seven categories based on their common domains, homology and functions, namely: fibril-associated collagens, reticular collagens, FACITs (fibril-associated collagens with interrupted triple helices), MACITs (membrane-associated collagens with interrupted triple helices) collagen), anchoring fibers, filament-forming collagen, MULTIPLEXIN (multiple triple helical domains and interruptions)/endostatin-producing collagen. In recent years, relevant studies have found that collagen is produced by pancreatic stellate cells (PSC) in the desmoplastic tissue matrix and promotes pancreatic cancer (PC) cell adhesion, proliferation, migration and chemical resistance. However, a large number of studies have found that the survival rate of patients with high matrix content is higher; the survival rate of cancer-stricken mice with cancer-associated fibroblasts (CAFs) genes removed is lower; the loss of type I collagen will accelerate Progression of pancreatic cancer. The above studies have confirmed that the stromal components of pancreatic cancer may affect the occurrence and development of pancreatic cancer through complex mechanisms. And it is closely related to the occurrence and development of pancreatic cancer. This article briefly summarizes the collagen proteins related to pancreatic cancer and the relationship between them, including type IV, type VI, and type X collagen, and is expected to become a tumor marker for pancreatic cancer and provide a preliminary theory for the diagnosis and treatment of pancreatic cancer. in accordance with. Collagen is a large family of triple helix proteins widely distributed throughout the body, and is a triple helix structure composed of three ¦Á-peptide chains. It can be divided into seven categories according to their common domains, homology and function, namely: fibrillar collagens , reticular collagens, FACITs (fibril-associated collagens with interrupted triple helices), MACITs (membrane-associated triple helices interrupted collagen), anchoring fibers, bead-forming collagen, MULTIPLEXIN (multiple triple helical domains and interruptions)/endostatin-producing collagen. Recent studies have found that collagen is produced by pancreatic stellate cells (PSC) in the connective tissue matrix and promotes cell adhesion, proliferation, migration and chemoresistance in pancreatic cancer (PC). However, a large number of studies have also found that patients with high stromal content have a higher survival rate; the survival rate of mice of cancer-associated fibroblasts (CAFs) gene deletion is lower; the loss of type I collagen will accelerate pancreatic cancer progression. The above studies have confirmed that the interstitial components of pancreatic cancer may affect the occurrence and development of pancreatic cancer through complex mechanisms. And it is closely related to the occurrence and development of pancreatic cancer. This article briefly summarizes the collagens related to pancreatic cancer and the relationship between them, including type IV, type VI , and type X collagen, which are expected to become tumor markers of pancreatic cancer and provide a preliminary theory for the diagnosis and treatment of pancreatic cancer.
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Original research was done by Huo Zheng, Zhao Zhanxue, Wu Jindu, Hou Xiaofan, Zhang Hao, Zhou Hongqian, Meng Kai, Zhao Dongyu, Liu Linxun
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