Expression Of Collagen Gene Mrna In Oral Squamous Cell Carcinoma Tissues
Keywords
Oral Squamous Cell Carcinoma, Collagen, Gene, Rt-Pcr
Abstract
Abstract: Objective To study the expression and significance of collagen genes col1a1, col1a2, col4a1, col4a2, col5a2 mRNA in oral squamous cell carcinoma (OSCC) and paired normal oral mucosal tissues. Methods RT-PCR method was used to detect the expression of collagen genes col1a1, col1a2, col4a1, col4a2 and col5a2 mRNA in tumor tissues of 30 OSCC patients and their paired normal oral mucosa; the obtained data were subjected to t test using the sas6.12 software package. Results RT-PCR detection results showed that the expression of col1a1 mRNA in OSCC was 2.78 times higher than that in control mucosa (p<0.001). The expression of col1a2, col4a1, col4a2, and col5a2 mRNA in OSCC was increased by 1.07, 1.15, 1.27, and 1.16 times respectively compared with its control mucosa (p>0.05). Conclusion During the process of oscc carcinogenesis, col1a1 mRNA is overexpressed and may be a target gene of oscc; col1a1 has application value in the classification diagnosis of oscc.
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Original research was done by Lu Xiaozhi, Chen Wantao, Zhang Chenping
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