Effect Of Collagen/Chitosan Oligosaccharide Composite Gel On The Differentiation Behavior Of Preosteoblast Mc3T3-E1S
Keywords
Chitosan Oligosaccharide, Collagen, Gel, Osteogenic Differentiation
Abstract
This article utilizes the biological activity of chitosan oligosaccharide (COS) and the good biological properties of collagen (Col) to construct collagen/chitosan oligosaccharide (Col/COSn) composite gels with different degrees of polymerization. Previously, osteoblast MC3T3-E1s were For example, the effect of the composite gel on cell proliferation and differentiation was evaluated from the perspective of cell proliferation and related osteogenic gene expression levels. The results show that compared with pure Col gel, all Col/COSn composite gels have varying degrees of promotion effects on the proliferation, differentiation and expression of osteogenesis-related genes of preosteoblast MC3T3-E1s. COS with different polymerization degrees There are obvious differences in the promotion effect among the composite gels. The composite gel containing chitotose (COS4) and chitohexaose (COS6) has a better effect on promoting cell proliferation than other groups, while the composite gel containing chitopentose (COS5) has a better effect on promoting cell proliferation. Glue is significantly better than other oligosaccharides in promoting cell differentiation and the expression of osteogenesis-related genes.
For further information of this article and research, feel free to contact our team for asssitance.
Original research was done by Ding Shan, Zhou Changren, Li Zhenzhen, Jia Weijian
About ETChem
ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.
ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.