Biological Basis And Characteristics Of Bone Marrow Mesenchymal Stem Cells Cultured On Collagen Membrane Biological Basis And Characteristics Of Bone Marrow Mesenchymal Stem Cells Cultured On Collagen Membrane
Keywords
Bone Marrow Mesenchymal Stem Cell,Collagen Membrane,Composite Culture, Bone Marrow Mesenchymal Stem Cell,Collagen Membrane,Composite Culture
Abstract
Abstract: Bone tissue formation is a remineralization process of extracellular matrix secreted by osteoblasts. Type 1 collagen is the main organic component of bone tissue. Its network structure has the function of anchoring and supporting cells, and can provide cell adhesion and microenvironment for proliferation. Collagen membrane can not only provide a spatial barrier for tissue regeneration, prevent cells from migrating out of the defect area to avoid cell loss; it also has a good early vascularization effect and can guide the growth of blood vessels, and new osteoblasts and bone formation-related cytokines can borrow new blood vessels. Migrate into the bone defect cavity to promote new bone formation. Compound culture of collagen membrane and bone marrow mesenchymal stem cells (BMMSC) can enhance the osteogenic ability of osteoblasts and stimulate the transformation of BMMSCs into osteoblasts. Collagen membrane is a good carrier for BMMSC adhesion and growth and can be used as a scaffold material for cells. This article traces the biological basis and characteristics of the composite culture of bone marrow mesenchymal stem cells and collagen membrane, aiming to explore methods for bone tissue repair and reconstruction. Abstract: China National Library Classification Number
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Original research was done by Xu Fan, Yang Desheng
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