Effects Of Effective Parts Of Red Stilbene On Collagen Area, Hyaluronic Acid And Laminin In Lung Tissue Of Rats With Pulmonary Interstitial Fibrosis Model

Keywords

Pulmonary Fibrosis, Effective Part Of Red Stilbene, Collagen Area, Hyaluronic Acid, Laminin, Rat

Abstract

Objective To observe the effect of red stilbene on the collagen area, hyaluronic acid (HA) and laminin (LN) expression in the lung tissue of rats with pulmonary interstitial fibrosis model, explore its mechanism of action, and screen the best effective parts of red stilbene. Methods 144 SPF Wistar rats were randomly divided into blank group, model group, prednisone group, and high, medium and low dose groups of red stilbene polysaccharide, flavonoids and saponins. The pulmonary fibrosis model was established by tracheal infusion of bleomycin. Starting from the second day after modeling, each drug group was given corresponding doses of drugs once a day for a total of 28 days. Masson staining was used to observe changes in collagen fibers in the lung tissue, and radioimmunoassay was used to detect the HA and LN contents in the lung tissue homogenates of rats in each group. Results Compared with the model group, alveolitis was significantly reduced in each dose group of red astragalus flavonoids and low-dose red astragalus polysaccharide group. The collagen area of the lung tissue in the low-dose group of red astragalus flavonoids, the medium-dose red astragalus polysaccharide group, and the low-dose red astragalus saponin group was significantly reduced. Compared with the model group, the HA content in the high-dose red astragalus polysaccharide group, each dose group of red astragalus flavonoids, and the high-dose red astragalus saponin group decreased significantly. The LN content in the high-dose red astragalus polysaccharide group, the mid- and low-dose red astragalus flavonoids group, and the mid- and low-dose red astragalus saponin group decreased significantly. Conclusion Red stilbene polysaccharide, flavonoids and saponins can all reduce alveolar inflammation, inhibit collagen fiber proliferation and deposition, and reduce HA and LN content in lung tissue at appropriate doses, among which red stilbene flavonoids have the better effect.

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Original research was done by 10.3969/j.issn.1005-5304.2016.04.019

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