Reduced Incidence And Severity Of Collagen-Induced Arthritis In Mice Lacking Lfa-1 Lfa-1 Gene Knockout Mice Reduced The Incidence And Severity Of Collagen-Induced Rheumatoid Arthritis

Keywords

Lfa-1 Collagen-Induced Arthritis, Rheumatoid Arthritis

Abstract

Lymphocyte function-associated antigen (LFA-1) belongs to a family of adhesion molecules and plays an important role in cell interactions. By observing the incidence, radiological and histological changes of collagen-induced arthritis (CIA) in LFA-1 gene knockout mice, the role of LFA-1 molecules in the pathogenesis of CIA was explored. The experiment used 100 ¦Ìg of type II collagen (CII) mixed with Freund’s complete adjuvant and injected intradermally into the tail base of LFA-1 knockout mice and normal control mice. The immunization was repeated 21 days later, and then the incidence rate was measured. , radiographic and histological analysis. Research results show that after CII immunization, the average incidence rate of mice in the normal control group was 57%, and obvious radiographic and histological abnormal changes were clinically visible. However, LFA-1 gene knockout mice showed no symptoms, and there were no obvious abnormal changes in radiographic and histological examinations. The above results suggest that LFA-1 plays an important role in the pathogenesis of collagen-induced arthritis.

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Original research was done by WANG Yi-nan,WANG Shi-yao,LIU Zhong-hui,CUI Xue-ling,TAI Gui-xiang, Wang Yinan, Wang Shiyao, Liu Zhonghui, Cui Xueling, Tai Guixiang

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