Effects Of Activin A And Follistatin On Secretion Of Hydroxyproline And Type Iv Collagen By Rat Renal Interstitial Fibroblasts

Keywords

Activin A, Follistatin, Fibroblasts, Type Iv Collagen, Hydroxyproline

Abstract

Objective To study the role of activin A (ACT-A) and follistatin (FS) in renal interstitial fibrosis. Methods SD rat renal interstitial fibroblasts were cultured in vitro and divided into group A, group F, and group A+F. ACT-A, FS, and ACT-A+FS were added to the culture medium respectively, and the culture medium was detected by ELISA. The contents of hydroxyproline (HYP) and type IV collagen (IV-C) in the supernatant. Results Within the concentration range of this study, the higher the concentration of ACT-A, the higher the concentration of HYP and IV-C in the culture medium; simply adding FS had no significant effect on the secretion of HYP and IV-C by rat renal interstitial fibroblasts ( P>0.05), but inhibited the effect of ACT-A on promoting the secretion of HYP and IV-C in rat renal interstitial fibroblasts in a dose-dependent manner (P<0.01). Conclusion ACT-A may play an important role in the occurrence and development of renal interstitial damage, and supplementing exogenous FS may provide new ideas for the treatment of renal interstitial fibrosis. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Li Furong, Yang Cheng, Zhang Ying, Yuan Fahuan  

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