Collagen Research

Keywords

Simvastatin, Liver Fibrosis, Transforming Growth Factor-¦¢1, Type I Collagen, Type Iii Collagen

Abstract

To observe the effect of simvastatin on liver fibrosis in rats and explore its mechanism. 60 healthy sleep deprivation (SleepDeprivation, SD) rats were randomly divided into control group, model group and drug group. In the model group and drug group, rats were subcutaneously injected with carbon tetrachloride (CCl4) oil solution to create a model. In the drug group, simvastatin (5 mg¡¤kg-1¡¤d-1) was administered by gavage at the same time until the end of the experiment; in the control group, Give an equal amount of olive oil subcutaneously. All animals were sacrificed after 8 weeks. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were detected by a fully automatic biochemical analyzer. Pathological changes in liver tissue were observed by hematoxylin-eosin staining and immunohistochemistry. The expression of type I and III collagen and transforming growth factor-¦Â1 (TGF-¦Â1) in liver tissues of each group was detected. The results showed that compared with the model group, the liver inflammatory reaction and fibrosis of rats in the drug group were milder, the expression of type I and III collagen and TGF-¦Â1 was significantly reduced (P<0.05), and the serum ALT and AST levels were reduced (P< 0.05). It can be concluded that simvastatin can reduce the degree of liver fibrosis, and its mechanism may be related to inhibiting the expression of TGF-¦Â1 and type I and III collagen. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Xu Ming, Sun Shen, Feng Panpan, Liu Jing  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

Abstract Collagen was extracted from fish skin using acetic acid and pepsin, and its physical and chemical properties were studied. The results showed that the extracted collagen belongs to typical type I collagen, and its triple helix molecular composition It is [¦Á1(¢ñ)]2¦Á2(¢ñ). The analysis of amino acid composition and denaturation temperature shows that the extracted fish skin collagen is much more stable than other fish due to its own subamino acid content. skin collagen, but it is still less stable than most mammalian skin collagen. UV scanning spectrum, Fourier transform infrared spectroscopy and circular dichroism research results prove that the extracted collagen triple helix structure remains intact

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About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

Some basic chemical components of grass carp skin were determined, the extraction process of grass carp skin collagen using enzymatic method was compared, and the amino acid composition, molecular weight distribution, denaturation temperature, etc. of the grass carp skin collagen were analyzed and measured. The results showed that: It is feasible to extract collagen from grass carp skin by enzymatic method, but the pretreatment of the skin should be strengthened. In the amino acid composition of grass carp skin collagen, the content of sub-amino acids (proline and hydroxyproline) is lower than the content of sub-amino acids in pig skin collagen; differential formula The scanning calorimeter measured the denaturation temperature of grass carp skin collagen at about 20¡ãC; the electrophoresis results showed that most of the proposed collagen maintained its natural triple helix structure, but some collagen may have been denatured.

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Original research was done by Zhang Yan, Li Guoying, Miao Yuqing, Chen Jianrong

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Nanohydroxyapatite, Alendronate, Type I Collagen, Surface Modification,

Abstract

Abstract Purpose: To prepare a stable and reproducible composite film of alendronate sodium (ALN) and type I collagen (COL I) on the surface of nanohydroxyapatite (nHA) coating. Method: nHA coating was electrochemically deposited on the surface of pure titanium (PT), using 3-aminopropyltriethoxysilane (APTES) and 1-ethyl-(3-dimethylaminopropyl)carbodiimide. Hydrochloride (EDC) is used as a coupling agent to combine ALN and COL I on the coating surface to prepare nHA/ALN/COL I and nHA/COL I/ALN composite films. The nHA coating was characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and X-ray diffractometer (XRD), and by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). Composite membrane. Results: ALN and COL I can be combined with the nHA coating through coupling agents, changing their binding order, and forming nHA/ALN/COL I and nHA/COL I/ALN composite films respectively. Conclusion: nHA/ALN/COL I and nHA/COL I/ALN composite membranes formed by chemical combination methods have different ALN sustained release potentials.

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Original research was done by JIANG Yan, YAO Jiang-Wu.

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Activin A, Follistatin, Fibroblasts, Type Iv Collagen, Hydroxyproline

Abstract

Objective To study the role of activin A (ACT-A) and follistatin (FS) in renal interstitial fibrosis. Methods SD rat renal interstitial fibroblasts were cultured in vitro and divided into group A, group F, and group A+F. ACT-A, FS, and ACT-A+FS were added to the culture medium respectively, and the culture medium was detected by ELISA. The contents of hydroxyproline (HYP) and type IV collagen (IV-C) in the supernatant. Results Within the concentration range of this study, the higher the concentration of ACT-A, the higher the concentration of HYP and IV-C in the culture medium; simply adding FS had no significant effect on the secretion of HYP and IV-C by rat renal interstitial fibroblasts ( P>0.05), but inhibited the effect of ACT-A on promoting the secretion of HYP and IV-C in rat renal interstitial fibroblasts in a dose-dependent manner (P<0.01). Conclusion ACT-A may play an important role in the occurrence and development of renal interstitial damage, and supplementing exogenous FS may provide new ideas for the treatment of renal interstitial fibrosis. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Li Furong, Yang Cheng, Zhang Ying, Yuan Fahuan  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Berberine, Diabetic Nephropathy, Glomerular Mesangial Cells, Transforming Growth Factor ¦¢1, Type Iv Collagen

Abstract

Objective: To explore the protective effect and mechanism of berberine on nephropathy in rats with diabetic nephropathy (DN). Methods: Streptozotocin (STZ) was used to replicate the DN rat model, and the animals were divided into normal control group, model group, and berberine low, medium, and high-dose treatment groups (50, 100, 200 mg¡¤kg-1¡¤d-1) , Xiaoke Pill treatment group (XKW, 0.8g¡¤kg-1¡¤d-1), fasting blood glucose (FBG), kidney weight/body weight ratio (KW/BW), urea nitrogen (BUN), creatinine ( Cr) and urine protein (Upro); immunohistochemistry detected the expression of transforming growth factor ¦Â1 (TGF-¦Â1) and type IV collagen (IV-C) protein in glomerular mesangial cells. Results: After ig administration, berberine could reduce the levels of FBG, KW/BW, BUN, Cr and Upro in rats, and reduce the expression of TGF-¦Â1 and IV-C protein in glomerular mesangial cells. Conclusion: Berberine has a protective effect on renal microcirculation lesions in DN rats, and this effect may be related to its inhibition of TGF-¦Â1 and IV-C protein expression in renal tissue.

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Original research was done by Tang Liqin, Lu Fei, Liu Sheng, Zhang Shantang

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

17¦¢-Estradiol Lung Fibroblast Caveolin-1 Type ¢ó Collagen 17¦¢-Estradiol Lung Fibroblast Caveolin-1 Type ¢ó Collagen

Abstract

Objective To explore the effects of different concentrations of 17¦Â-estradiol (17¦Â-E2) on the expression of Caveolin-1 and type III collagen in mouse lung fibroblasts stimulated by silicon dioxide (SiO2). Methods Mouse lung fibroblasts cultured in vitro were divided into 5 groups: blank control group, SiO2 (100 mg/L) group, SiO2 (100 mg/L) + different doses of 17¦Â-E2 group (10-8, 10-7 , 10-6 mol/L), cells in each group were collected after 48 h of 17¦Â-E2 treatment, and immunohistochemistry was used to detect the expression of Caveolin-1 and type III collagen. Results Compared with the blank control group, the expression of Caveolin-1 in the lung fibroblasts of mice in the SiO2-treated group was reduced (P<0.05), while the expression of Caveolin-1 in the SiO2+ 17¦Â-E2-treated group increased significantly as the dose of 17¦Â-E2 increased (P <0.05); the difference in expression of type III collagen in each treatment group was statistically significant (P<0.05). The SiO2 group was higher than the blank control group (P<0.05), while the 17¦Â-E2 treatment group was lower than the SiO2 group (P<0.05). 0.05); correlation analysis showed that 17¦Â-E2 was positively correlated with the expression of Caveolin-1 (r=0.926, P<0.05), and negatively correlated with the expression of type III collagen (r=-0.914, P<0.05). Caveolin-1 There was also a negative correlation with the expression of type III collagen (r=-0.887, P<0.05). Conclusion 17¦Â-E2 may exert anti-fibrotic effects by upregulating the expression of Caveolin-1 in lung fibroblasts and inhibiting the expression of type III collagen. Objective To observe the effects of different concentration of 17¦Â-estradiol (17¦Â-E2) on the expression of Caveolin-1 and type III collagen in the mouse lung fibroblast stimulated by SiO2. Methods Fibroblast cells were devided into five groups: blank control group, SiO2 (100 mg/L) group and SiO2 (100 mg/L)+ different concentration of 17¦Â-E2 (10-8, 10-7, 10-6 mol/L) groups. After treated with different concentration of 17¦Â-E2 , for 48 h, the cells were collected, then the expression of Caveolin-1 and of type ¢ó collagen were examined with immunohistochemistry method. Results Compared with the blank control group, the expression of Caveolin-1 in mouse lung fibroblasts treated by SiO2 significantly decreased (P <0.05), While which in the SiO2+17¦Â-E2 group significantly increased as 17¦Â -E2 dose increased (P < 0.05); There were significantly different in the expression of type ¢ó collagen among different groups (P <0.05) , which in SiO2 group were evidently higher than that in the blank control group, while which in 17¦Â-E2 groups decreased significantly, when compared with SiO2 group (P <0.05); 17¦Â-E2 increased the expression of Caveolin-1 and decreased the expression of type ¢ó collagen in the dose dependent manner. Correlation analysis showed that 17¦Â-E2 was positively correlated with the expression of Caveolin-1 (r=0.926, P <0.05), and negative correlated with the express of type ¢ó collagen (r =-0.914, P <0.05), and the expression of Caveolin-1 and the expression of type ¢ó collagen was negatively correlated (r=-0.887, P <0.05). Conclusion 17¦Â-E2 may inhibit the expression of type ¢ó collagen by up-regulating the expression of Caveolin-1 in mouse lung fibroblast cells to play a role in the resistance of the lung fibrosis. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Xiao Yonghong, Liang Xiaofei, Wang Yue, etc.  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

Collagen and collagen-based materials are widely used in biomedical, leather, food, daily chemical industry and other fields. During the process of processing, application and storage, collagen is often affected by light, temperature and humidity changes, pH value changes, salt solution immersion, and bacterial and mold erosion, which changes the structure of the material and leads to changes in performance. This article reviews the main factors that cause changes in the structure and properties of collagen, and explains the changes in the thermal stability, triple helical chain structure and aggregated structure of collagen under the action of ultraviolet light irradiation, acid and alkali solutions, salt solutions and organic solvents, and heat. .

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Original research was done by Wang Kun, Zheng Xuejing, Meng Zhuojun, Tang Keyong

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Scale Collagen Peptide Protease Hydrolysis Degree Of Hydrolysis Antioxidant Activity Emulsifying Property Ish Scale Collagen Peptide Protease Hydrolysis Degree Of Hydrolysis Antioxidant Activity Emulsifying Property

Abstract

Using grass carp (Ctenopharyngodon idellus) scales as raw materials, the effect of the hydrolysis process on the properties of enzymatically prepared fish scale collagen peptides under the action of three commonly used industrial proteases was studied. The results showed that: for alkaline protease, after hydrolysis for 4 hours under the test conditions, the degree of hydrolysis was 9.5%. At this time, the comprehensive performance of collagen peptide was the most ideal, the clearance rate of DPPH? was 82.14%, and the emulsification activity index was 70.12 m2 /g. For the complex protease, after hydrolysis for 4 hours under experimental conditions, the degree of hydrolysis was 8.7%, the clearance rate of DPPH? by collagen peptide was 86.32%, and the emulsification activity index was 32.93 m2/g. For neutral protease, after hydrolysis for 4 hours under experimental conditions, the degree of hydrolysis was 7.2%, the clearance rate of DPPH? by collagen peptide was 70.15%, and the emulsification activity index was 36.88 m2/g. The above results show that there are differences in the properties of collagen peptides with different degrees of hydrolysis. Different proteases are used for hydrolysis. When the degree of hydrolysis is the same, the properties of the obtained collagen peptides are also different. Three kinds of industrial proteases were applied to investigate the effect of hydrolysis process on the functional properties of crass carp(Ctenopharyngodon idellus) scale derived collagen peptide.The results revealed that collagen peptide with different DH and the same DH by different proteases showed different properties. For alcalase 2.4L FG group,after 4 h of hydrolysis,the clearance of DPPH free redical,emulsifying activity index (EAI) and DH were 82.14%,70.12 m2/g and 9.5%,respectively.For protamex group and neutrase 1.5 MG group , after 4 h of hydrolysis, the DH of collagen peptide were 8.7% and 7.2%, the clearance of DPPH free redical were 86.32% and 70.15%, and the EAI were 32.93 m2/g and 36.88 m2/g, respectively.

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Original research was done by Hu Yang, Yang Lili, Xiong Shanbai, Liu Youming, You Juan, Yin Tao

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Bee Venom, Capsaicin Receptor, Tyrosine Kinase A, Rheumatoid Arthritis, Collagen-Induced Arthritis

Abstract

Objective To explore the effect of bee venom on TrkA and TRPV1 pain signaling molecules in rats with collagen-induced arthritis (CIA). Methods: The subjects were divided into normal control group, model group and bee venom group (BV, 3 mg/mL). Wistar male adult rats and Collagen ¢ò+IFA 0.2 mL were used to create the model. In the BV group, medication was started 14 days after modeling and continued until 21 days; the plantar thickness, pain threshold and swollen joint scores of each group were recorded. IHC was used to observe the expression of TRPV1 in pathological sections of the dorsal root ganglion and western bolting was used to observe the expression of TrkA. To evaluate the intervention of bee venom on the ankle joint of CIA rats. Results: The swelling started on the 10th day after the modeling, and all signs of CIA appeared within 14 days. The thickness of the sole of the foot and the swollen joint score showed an overall gradually increasing trend. It levels off at 14 days. The BV group was treated with 0.3 mg of bee venom for 7 days. The thickness of the plantar and swollen joint scores of the BV group were lower than those of the model group. Pain threshold (seconds): normal control group 15.47¡À0.35, model group 10.90¡À0.10, BV group 13.14¡À0.18. Immunohistochemistry percentage of TRPV1-positive cells (%): 11.40¡À1.48 in the normal control group, 44.47¡À4.38 in the model group, and 21.60¡À2.20 in the BV group. Western blotting was used to observe TrkA expression (gray value): 1.59¡À0.04 in the normal control group, 4.53¡À0.21 in the model group, and 2.46¡À0.17 in the BV group. Conclusion Bee venom injection can reduce the expression levels of DRG signaling molecules TrkA and TRPV1 in rats with inflammatory pain. This may be one of the anti-inflammatory and analgesic signaling pathways, providing new inspiration for the treatment of rheumatoid arthritis with bee venom.

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About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.