Collagen Research

Keywords

Collagen-Induced Arthritis Coixinate Foxp3+Cd4+Cd25+ Treg

Abstract

Objective To study the effect of coixenolate on Foxp3+CD4+CD25+ regulatory T cells (Treg) in the peripheral blood of mice with collagen induced arthritis (CIA), and to explore the possibility of coixenolate in the treatment of rheumatoid arthritis. mechanism. Methods Five mice were randomly selected from 25 mice as the normal group, and the remaining 20 mice were used for CIA modeling. After successful modeling, they were randomly divided into a modeling control group of 10 animals and a coixenolate group of 10 animals. The coixolate group was given coixolate injection 25 mL/kg, and the normal group and the modeling control group were injected with normal saline 25 mL/kg, both intraperitoneally once a day. Take the medicine together for 21 days. After medication, arthritis scores in each group were scored, arthritis index was calculated, and flow cytometry was used to determine the proportion of Foxp3+CD4+CD25+ Treg in the peripheral blood of mice. Results Compared with the normal group, the arthritis index of mice in the modeling control group was significantly increased (P<0.01), and the arthritis index of mice in the coixenolate group was significantly decreased compared with the modeling control group (P<0.01). Compared with the normal group, the levels of Foxp3+CD4+CD25+Treg in the modeling control group were significantly decreased (P<0.01). The levels of Foxp3+CD4+CD25+Treg in the coixenolate group were significantly higher than those in the modeling control group after treatment. The difference There is statistical significance (P<0.01). Conclusion Coixin can increase the proportion of Foxp3+CD4+CD25+Treg in CIA mice and may have a certain immunoregulatory effect in the pathogenesis of CIA. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Zhou Hongjuan, Zhang Wen, Zhang Weiming, Zheng Hongxia  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Fermentation Collagen Hydrolysate (Ch) Biomass Bacillus Subtilis Nitrogen Source Fermentation Collagen Hydrolysate (Ch) Biomass Bacillus Subtilis Nitrogen Source

Abstract

Study the effect of collagen hydrolysate (CH) on the growth of Bacillus subtilis to provide a theoretical basis for the resource utilization of CH in the field of fermentation. Determine the effects of different nitrogen sources (CH, peptone, gelatin, NaNO3, NH4Cl) on the growth of Bacillus subtilis; examine the effects of different ratios of CH and corn steep liquor on the growth of Bacillus subtilis; study the effects of different carbon The influence of CH on the growth of Bacillus subtilis; the influence of CH on the fermentation of other bacteria. The study found that when CH is the nitrogen source, the fermentation process of Bacillus subtilis can proceed smoothly, and the biomass of microorganisms can be maintained at a high level; compared with corn steep liquor, CH can enable Bacillus subtilis to reach a higher biomass. amount; when CH is used as the nitrogen source, starch is more conducive to the growth of Bacillus subtilis than glucose and sucrose; in addition to Bacillus subtilis, Escherichia coli ATCC 15489 and Bacillus licheniformis CICC 20031 are also effective Utilize CH. This suggests that hydrolyzed collagen (CH) can serve as a nitrogen source for fermentation by a variety of microorganisms under experimental conditions. In the present study, the effect of collagen hydrolysate (CH) on the growth of Bacillus subtilis was investigated for its valuable utilization in the fermentation industry. The influences of CH and other nitrogen sources, the proportion of CH and corn steep liquor, and the different carbon source at the present of CH on the growth of B. subtilis were significantly explored. Further, the effects of CH as nitrogen source on the fermentation for several bacteria was also investigated. With a positive effect on the biomass of Bacillus subtilis, CH was observed to be a suitable nitrogen source for the microbial fermentation. Comparing with corn steep liquor, CH exhibited a strong ability to improve the growth of Bacillus subtilis and keep its biomass in a high level. However, starch was a better carbon source than glucose and sucrose for the growth of Bacillus subtilis with the present of CH. Moreover, CH showed the significant value to be used as the nitrogen resource for the growth of Escherichia coli (ATCC 15489) and Bacillus licheniformis (CICC 20031). This suggests that CH possesses the potential to be utilized as a nitrogen resource for the growth of multiple microorganisms in the fermentation industry

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Original research was done by Li Xia, Zhu Deyi, Zeng Weicai, Tian Cuicui, Liao Xuepin, Shi Bi

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Paeoniflorin, Collagen-Induced Arthritis, Glucocorticoid Receptor, Reverse Transcription-Polymerase Chain Reaction

Abstract

To study the effect of paeoniflorin (PF) on the glucocorticoid receptor (GCR) of peripheral blood mononuclear cells (PBMCs) in rats with collagen-induced arthritis. The collagen-induced arthritis (CIA) rat model was used. On the 14th day after the initial immunization, PF25, 50, 100mg¡¤kg-1 or triptolide 20¦Ìg¡¤kg-1 or PF50mg¡¤kg-1+RU48615mg¡¤ were administered intragastrically. kg-1, once a day, administered continuously for 28 days. On the 2nd day after the last dose, all experimental rats except the PF+RU486 group had their eyeballs removed to collect blood. They were sacrificed and unimmunized joints were collected from all rats. The expression of GCR¦Á and GCR¦Â in PBMCs was detected by ELISA and reverse transcription-polymerase chain reaction. The expression of GCR¦Á and GCR¦Â mRNA in PBMCs was analyzed by (RT-PCR) method, and the expression of IL-1¦Â, NF-¦ÊBp65, TNF-¦Á, and PGE2 in joint synovial tissue was analyzed by immunohistochemistry. PF50, 100mg¡¤kg-1 can inhibit the expression of IL-1¦Â, NF-¦ÊBp65, TNF-¦Á, and PGE2 in the synovial tissue of CIA rats (P<0.05, P<0.01), while RU48615mg¡¤kg-1 can significantly affect This effect of PF50mg¡¤kg-1 (P<0.05); PF50 and 100mg¡¤kg-1 can upregulate the expression of GCR¦Á and GCR¦ÁmRNA, and downregulate the expression of GCR¦Â and GCR¦ÂmRNA (P<0.01). PF inhibits the joint synovium of CIA rats. Inflammatory mediators may be related to their regulation of GCR expression. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Yi Jianfeng  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

Abstract Antifreeze peptides are a type of polypeptide that can non-colligatively reduce the freezing point of a system and play a very important physiological role in life. An ice-affinity adsorption device was built in the study, and microbial protective activity was used as an indicator to optimize its effect on pigs. The adsorption conditions of collagen antifreeze peptides in the enzymatic hydrolysis complex of skin collagen were studied, and the properties of the isolated products were studied. The results showed that the concentration of the enzymatic collagen hydrolysis complex was 1 mg/mL, the adsorption time was 10 h, and the adsorption temperature was – Under the conditions of 5¡ãC and 2 adsorption times, the obtained collagen antifreeze peptide has the strongest low-temperature protective activity against microorganisms. After ice affinity adsorption, the separation effect between the main elution peaks of the collagen antifreeze peptide increased significantly. , the molecular mass of its collagen antifreeze peptides is mainly less than 1 000 Da, and is rich in glycine, proline and hydroxyproline

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About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Tilapia Scale Collagen Peptides Antioxidant Activity Cryoprotective Activity Amino Acid

Abstract

Tilapia scales were used as raw materials, and alkaline protease and trypsin were used for compound hydrolysis. On the basis of single factor experiments, the response surface method was used to optimize the enzymatic hydrolysis process to prepare fish scale collagen peptides. The antioxidant activity and bacterial low temperature of collagen peptides were measured. Protective activity, amino acid composition and relative molecular mass distribution. The results show that the optimal enzymatic hydrolysis conditions are: substrate mass concentration 30.6 mg¡¤mL-1, and the amount of trypsin and basic protein added are 1.44 and 0.70 mg¡¤mL respectively. -1. Enzymatic hydrolysis temperature is 50¡æ, pH value is 8.5, and enzymatic hydrolysis time is 6.35h. The half-mass scavenging mass concentrations (IC50) of enzymatically hydrolyzed collagen peptides for DPPH free radicals and hydroxyl free radicals are 2.89 and 3.54 mg¡¤mL-1 respectively. After a bacterial low-temperature protection test, when the mass concentration of collagen peptide is 1 mg¡¤mL-1, the survival rate of Streptococcus thermophilus reaches 75.6%. The relative molecular mass distribution of fish scale collagen peptide shows that the relative molecular mass of 78% of the polypeptide fragments is distributed in 180 Between ~2000u. Amino acid composition analysis shows that fish scale peptides are rich in glycine, alanine, proline, hydroxyproline and aspartic acid. These specific amino acids are related to the antioxidant activity and bacterial low-temperature protection activity of collagen peptides. Related. The scale of Tilapia was used in the experiment as the raw material, which was hydrolyzed by alkaline and trypsin protease. The response surface method according to single factor analysis was optimized to prepare fish scale collagen peptides. Antioxidant effects, hypothermia protection activity on bacteria, amino acid composition and molecular weight distribution of collagen peptides were analyzed. The results indicated that the optimum conditions for enzymatic hydrolysis were determined as follows: substrate concentration of 30.6mg¡¤mL-1, enzyme dosage of trypsin and alkaline protease were 1.44 and 0.70mg¡¤mL-1, hydrolysis temperature of 50¡æ, pH 8.5 and hydrolysis time of 6.35h, respectively. The IC50 of enzymatic collagen peptides on scavenging DPPH¡¤and¡¤OH were 2.89 and 3.54mg¡¤mL-1, respectively. hypothermia protection assay showed that the survival rate of Streptococcus thermophiles was 75.6% when the concentration of peptides was 1mg¡¤mL-1. Molecular weight distribution showed that 78% of collagen peptides mostly distributed between 180 to 2000u, and it was rich in Gly, Ala, Pro, Hyp and Asp, which were special amino acids relative to the antioxidant activity and cryoprotective activity

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Original research was done by Li Ling, Xu Liangzong, Wang Shaoyun

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

The effects of temperature, time and acetic acid concentration in the process of extracting carp scale collagen by acid method were studied, and SAS was used to perform regression analysis on the influencing factors. The optimal conditions for carp scale collagen extraction were obtained, with temperature of 18¡ãC and extraction time. 38 h, the acetic acid concentration is 1.3 mol/L, before extraction, the use of Na22CO3 treatment can greatly improve the extraction of collagen. Provide a theoretical basis for the comprehensive processing and utilization of freshwater fish.

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Original research was done by Zhang Junjie, Duan Rui, Chen Lu

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

Collagen has a unique 3-stranded helical structure, excellent biocompatibility and biodegradability, and has great application prospects. In order to further expand the application fields of cellulose and develop new green cellulose fibers, sodium periodate was used to perform local limited selective oxidation of cotton fibers, and then reacted with collagen solution to prepare collagen-coated cotton fibers. The results show that the breaking strength of cotton fibers does not decrease significantly after limited oxidation by sodium periodate; collagen molecules are covalently bound to the surface of cotton fibers through Schiff base CN double bonds.

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About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

Jellyfish collagen peptide was obtained by enzymatic hydrolysis of jellyfish collagen to study its immunoregulatory effect on mice. Jellyfish collagen peptide was administered to mice and the immune organ index, macrophage phagocytosis function, spleen lymphocyte proliferation function and other immune functions were measured. Functional indicators. Test results show that high-dose jellyfish collagen peptide can significantly increase the carbon clearance index K, phagocytosis index ¦Á and spleen index of mice, and significantly promote the proliferation of T lymphocytes induced by concanavalin.

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Original research was done by Ding Jinfeng, Yue Fupeng, Li Yanyan, Su Xiurong, Jiang Xin, Gao Xiang

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Abstract

Abstract In order to increase the added value of rabbit industry products, a new raw material collagen product was developed. Rabbit skin was used as raw material and collagen was extracted using enzymatic method. Using the collagen extraction rate as an indicator, the pepsin dosage, enzymatic hydrolysis solution pH and enzymatic hydrolysis time were studied. The influence of three factors on the collagen extraction process determines the optimal extraction conditions for collagen. The results of single factor experiments and orthogonal experiments show that the optimal conditions are the pH value of the enzymatic hydrolyzate solution of 1.9, the enzymatic hydrolysis time of 4 hours, and the dosage of pepsin. 1% (w/w), under these conditions, the extraction rate of collagen was (94.17¡À0.57)%, and the purity was (86.12¡À0.15)%. The results of polyacrylamide gel electrophoresis showed that rabbit skin collagen It is mainly composed of three subunit components, ¦Á, ¦Â and ¦Ã, and is type I collagen. Differential calorimetry scanning results show that the thermal cross-linking temperature of this collagen is 44.59¡ãC and the thermal enthalpy value is 1.386 8 J/g. It has High thermal stability

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About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Articular Cartilage Type ¢ò Collagen Fiber Treadmill Training Leucine Repeat-Rich Small Molecule Proteoglycan Cartilage Type ¢ò Collagen Treadmill Running Slrps

Abstract

Objective To explore the effects of treadmill training at different intensities on the morphology and gene expression of collagen fibers in rat knee joint cartilage. Methods 48 male SD adult rats were divided into control group, low-intensity exercise group, medium-intensity exercise group and high-intensity exercise group using random number table method. Rats in the three exercise groups performed low-, medium-, and high-intensity treadmill exercise respectively. All experimental animals were sacrificed 8 weeks after the experiment, and knee joint cartilage specimens were taken for Sirius red-saturated picric acid staining to observe the arrangement of collagen fibers, and immunohistochemistry was used to detect the content of type II collagen (Col2); in addition, this study also used real-time Fluorescence quantitative reverse transcription polymerase chain reaction was used to detect cartilage biglycan (BGN), fibromodulin (FMOD) and type ¢ò collagen (Col2) mRNA expression. Results In the control group, the collagen fibers of the knee joint cartilage were arranged regularly; there were significant differences between the low- and medium-intensity exercise groups and the control group; in the high-intensity exercise group, the collagen was irregularly arranged and the number of fine fibers increased; in the high-intensity exercise group, the type II collagen content was significantly lower than that in the control group. Control group. Compared with the control group, the expression of Col2 mRNA in chondrocytes in the low-intensity exercise group was significantly increased, and the expression of BGN mRNA in the high-intensity exercise group was significantly increased. Conclusion Low- and medium-intensity exercise can help maintain the normal structure and function of articular cartilage; high-intensity exercise can promote the reduction and disorder of type II collagen fibers in articular cartilage, but cartilage self-repair may also occur at the same time. Objective To investigate the effect of treadmill running with different intensities on type¢òcollagen (Col2) of knee joint articular cartilages in rats. MethodsA total of 48 adult Sprague-Dawley rats were randomly divided into a control (C) group, a low-intensity exercise ( L) group, a moderate- intensity exercise (M) group and a high-intensity exercise (H) group, each of 12. Rats in three exercises groups were regularly trained on treadmill at low, moderate, and high intensities respectively. Eight weeks later, all the animals were sacrificed. The right tibial plateau samples were collected to observe collagen fibers under polarizing light microscopy, and the collagenII content were examined using immunohistochemistry. The mRNA expression of biglycan (BGN), fibromodulin (FMOD) and Col2 was tested using the quantitative real-time reverse transcription-polymerase chain reaction. ResultsCompared with group C, collagen fibers in group L and M exhibited almost the same organization, whereas, alteration in organization and shape of collagen fibers was found in group H. Significantly lower content of type ¢ò collagen was found in group H than that in group C. In comparison with group C, group L had significantly higher gene expression of Col2, whereas group H had significantly higher BGN mRNA expression. ConclusionLow- or moderate-intensity treadmill running appears to have beneficial effect on articular cartilages to maintain its integrity. High-intensity exercises induce lower content and disorder of type II collagen in articular cartilages, but the self-healing of cartilage may still exist

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Original research was done by Zhou Yuezhu, Lei Lei, Liu Shengyao, Ni Guoxin

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.