Collagen Research

Keywords

Deer Antler, Collagen, Extraction, Optimization

Abstract

Using sika deer antler as raw material, the collagen content and collagen extraction effect in velvet antler at different growth stages were studied and the appropriate extraction conditions were determined. The pepsin method was used to extract collagen, and the Box-Behnken central combination experimental design was used to optimize the collagen extraction conditions. The results show that the collagen content and yield in Ergongzhi are higher than those of Trichosanthes trichophylla and Trichosanthes trichosanthes, which are 65.8mg/g and 4.53% respectively. The suitable process conditions for collagen extraction are extraction time of 52h, enzyme dosage of 5%, and liquid-to-material ratio. 23:1 (mL/g), under these conditions, the yield of velvet antler collagen is 5.92%

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Original research was done by Wang Shanshan, Zhao Yuhong, Jin Xiuming

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Ace Inhibitory Peptide, Collagen, Enzymatic Hydrolysis

Abstract

Based on the amino acid composition of collagen and the structure and activity characteristics of ACE inhibitory peptides, the potential ACE inhibitory active peptides in the collagen sequence are analyzed, and the current research status of collagen ACE inhibitory peptides is summarized; on this basis, the research on collagen ACE inhibitory peptides is analyzed problems existing in the process, and put forward prospects for solving the problems, in order to provide certain reference for the development and in-depth research of collagen ACE inhibitory peptides.

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Original research was done by Liu Yi, Zhang Yuhao, Ma Liang

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Elephant Skin, Collagen, Antioxidant

Abstract

Objective: To study the collagen structure and antioxidant activity of traditional Chinese medicine elephant skin and its intended substitutes, pig skin and fish scales. Methods: Through the orthogonal experimental design method, the optimal extraction conditions of elephant skin collagen were optimized. The structure and content of elephant skin collagen were compared with those of the proposed substitute collagen. The salicylic acid method was used to determine their respective hydroxyl radical scavenging abilities. Results: For the first time, collagen with a complete structure and high quality was extracted from elephant skin. The structural type of collagen is similar to that of the proposed substitute. The IC50 of the free radical scavenging ability of elephant skin collagen, pig skin collagen, and fish scale collagen were 0.51 respectively. 0.60,0.42g¡¤L-1. Conclusion: Through comparison and identification, elephant skin collagen is type I collagen with strong antioxidant capacity. The active ingredients of elephant skin are clarified, which provides an important reference for further research on elephant skin substitutes in the future.

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Original research was done by Li Chunnan, Sun Jiaming, Zhang Hui

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Astragalus, Collagen, Angiogenesis

Abstract

Objective: To load Astragalus membranaceus into the collagen scaffold, and by modifying the collagen scaffold, observe whether Astragalus membranaceus has pro-angiogenic activity and explore the possible biological mechanism. Methods: Load 5 or 10 ¦ÌL of Astragalus injection into modified collagen, and pass it through the Chicken Chorioallantoic Membrane (CAM) experimental model to determine the number of regenerated microvessels around the collagen, hemoglobin content in the collagen, dry weight of collagen, and CD34 antigen. Immunohistochemical markers and other indicators were used to examine the effect of Astragalus injection on promoting vascular regeneration after heparin-modified collagen. Results: Astragalus combined with heparin-modified collagen can produce a therapeutic effect equivalent to that of vascular endothelial growth factor. Blood vessel count, collagen hemoglobin content, and CD34 expression were all significantly increased (P<0.01, compared with the pure collagen group); compared with the pure collagen group In comparison, the dry weight of collagen in the collagen + astragalus 10ul group increased significantly (P<0.05). Conclusion: Astragalus injection loaded with modified collagen has a good effect on promoting vascular regeneration. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Yan Shihai*, Zhu Xuanxuan, Chen Xiaohu, Li Qiyi, Gong Ren, Yao Chang, Zhu Changle  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Grass Carp, Collagen, Thermal Denaturation, Collagen Sponge, Material Properties

Abstract

Natural collagen was extracted from grass carp skin, and was confirmed to be type I collagen with a complete triple helix molecular structure by DSC, circular dichroism and SDS-PAGE analysis. After heat treatment of the collagen under different conditions, low-denaturation, high-denaturation and completely-denatured collagen samples were obtained respectively. The thermal denaturation enthalpy measurement results showed that the thermal denaturation degrees were: 16.9%, 57.9% and 100% respectively. On this basis, we focused on studying the changes in collagen structure and collagen sponge material properties after thermal denaturation treatment. Experimental results show that the starting temperature of grass carp skin collagen denaturation (To, 33¡ãC) is the threshold temperature for changes in its molecular structure and collagen sponge material properties. A brief heating history above this temperature can lead to partial or complete dissociation of the collagen triple helix structure. At the same time, as the degree of collagen denaturation increases, the orderliness of its material structure, material mechanical properties and resistance to enzymatic hydrolysis also decrease, but its ability to promote cell proliferation increases. The above research results confirm that lower than the starting temperature of thermal denaturation of collagen is a safe temperature condition for natural collagen extraction and collagen material application.

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Original research was done by Wang Haibo

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Fibril Formation, Type Ii Collagen, Cartilage

Abstract

The extraction and purification method of type II collagen was established, and the kinetics of collagen fibril formation, stability and ultrastructure of collagen fibrils of rat cartilage type II collagen in vitro were observed. The results show that the resting phase and growth phase of type II collagen are 15 and 120 minutes respectively, the gelation rate in the growth phase is 0.0060, and the gel resiliency is 13.58%. The collagen fibrils show a typical natural fiber structure with 64nm periodic striations, but The fiber diameter increases compared to the body. These are of great significance for studying the formation process and regulatory mechanism of collagen fibrils in vivo.

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Original research was done by Fu Zhihou, Zhang Yanyuan

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Microwave Treatment, Pig Skin, Collagen

Abstract

In order to maintain the biological activity of collagen and improve the yield, microwave technology is used to extract pig skin collagen. A single factor experiment was conducted to study the effects of four factors: microwave treatment temperature, microwave treatment time, solid-liquid ratio, and extraction time on the collagen extraction rate, and determine the optimal process conditions for microwave-assisted collagen extraction. The results show that under the conditions of microwave time 2 minutes, microwave temperature 25¡ãC, solid-liquid ratio 1:30 (g/mL), and extraction time 35 hours, the extraction rate of pig skin collagen is 76.72%.

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Original research was done by Li Xingwu, Li Hongjun

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.