Collagen series

Keywords

Type I Collagen Pyridine Cross-Linked Terminal Peptide, Lung Cancer, Bone Metastasis, Diagnostic Value, Meta Analysis, Systematic Review

Abstract

Objective To systematically evaluate the diagnostic value of bone metabolism index cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) in lung cancer bone metastasis. Methods A computer search was performed on The Cochrane Library, PubMed, EMbase, WanFang Data and CBM database to collect relevant studies on ICTP diagnosis of lung cancer bone metastasis. The search time limit was from the establishment of the database to November 2017. Two researchers independently screened the literature, extracted data, and used the QUADAS-2 tool to evaluate the risk of bias of the included studies, and then used Meta-Disc 1.4 software to conduct a meta-analysis. Results A total of 8 studies were included, including 781 patients. Meta-analysis results show that the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under the SROC curve of ICTP in diagnosing lung cancer bone metastasis are 71% respectively [95% CI (0.65, 0.76)] , 80% [95%CI (0.76, 0.84)], 3.79 [95%CI (2.31, 6.21)], 0.35 [95%CI (0.25, 0.49)], 14.67 [95%CI (6.99, 30.81)] and 0.860 3. Conclusion ICTP has certain diagnostic value for bone metastasis of lung cancer, and it can be helpful for diagnosis in conjunction with bone scan and other imaging methods. Due to limitations in the quantity and quality of included studies, more studies are needed to confirm the above conclusions.

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Original research was done by Yu Xijie, Zhao Qian

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Tooth Extraction, Space Maintenance, Alveolar Bone Loss, Biocompatible Materials, Molars

Abstract

Purpose: To compare with natural healing, to observe the alveolar bone height and alveolar bone height after 6 months of healing when molars with bone defects were extracted and simultaneously implanted with deproteinized bovine bone matrix (bio-oss?) and covered with absorbable collagen membrane (bio-gide?). width changes. Methods: A total of 18 molars from 16 patients extracted due to periodontal disease were included in this study and divided into a control group (natural healing group after tooth extraction) and an experimental group (preservation of tooth extraction sites using deproteinized bovine bone matrix and absorbable collagen membrane). Group). Parallel projection periapical radiographs and cone-beam computed tomography (cbct) examinations were taken immediately after surgery and 6 months after surgery. The alveolar bone height and alveolar bone height at 6 months after surgery were evaluated through periapical radiographs and CBCT measurements. width changes. Results: Six months after surgery, the alveolar bone heights in the central and distal buccal sides of the test group increased by 2.90mm and 1.45mm respectively, while in the control group, the alveolar bone heights in the central and distal buccal sides decreased by 1.00mm and 1.45mm respectively. The difference between the two groups was statistically significant (p<0.05), but the difference in bone width changes between the two groups was not statistically significant (p>0.05). Conclusion: Preserving molars with bone defects using deproteinized bovine bone matrix and absorbable collagen membrane at the extraction site can significantly increase the height of the buccal alveolar bone and the width of the alveolar bone at 1mm and 4mm above the alveolar crest.

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Original research was done by Zhan Yalin, Hu Wenjie, Zhen Min, Xu Tao, Lu Ruifang

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Liver X Receptor, Fibroblast, Transforming Growth Factor Beta 1, Basic Fibroblast Growth Factor

Abstract

Objective To explore the effect of liver X receptor agonist T0901317 on the proliferation, migration and collagen secretion function of human embryonic lung fibroblasts. Methods Human embryonic lung fibroblasts were cultured and divided into control group, T0901317 group, growth factor group, and growth factor + T0901317 group. The cells in the control group were only cultured with serum-depleted Dulbecco’s modified Eagle culture medium, the T0901317 group was added with 1.00 ¦Ìmol/L T0901317 intervention, and the growth factor + T0901317 group was incubated with 0.25, 0.50, and 1.00 ¦Ìmol/L T0901317 for 2 h respectively. Recombinant human basic fibroblast growth factor and recombinant human transforming growth factor ¦Â1 were added together with the growth factor group and cultured for 24 h. Cell counting kit 8 was used to detect cell proliferation, Transwell method was used to detect cell migration, and hydroxyproline assay was used to detect the ability of cells to secrete collagen. Results Compared with the control group, the proliferation, migration and collagen secretion abilities of cells in the T0901317 group had no significant changes, while the proliferation, migration and collagen secretion abilities of cells in the growth factor group were significantly enhanced. T0901317 can inhibit growth factor-induced fibroblast proliferation, migration and collagen secretion. The greater the concentration of T0901317, the more obvious the inhibitory effect. Conclusion T0901317 may inhibit the proliferation, migration and collagen synthesis of human embryonic lung fibroblasts by inhibiting growth factor function.

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Original research was done by Tan Yan, Gu Wei

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Leydig Cells, Trypsin, Collagenase Ii, Lipid Droplets, Mice

Abstract

Abstract Purpose: To compare the separation effects of four enzyme mass concentrations on primary mouse testicular Leydig cells. Methods: The testicles of 20 adult male Kunming mice were evenly divided into A, B, C and D4 groups, and were digested and separated with 0.05%, 0.125%, 0.25% trypsin and 0.02% collagenase II respectively. Testicular Leydig cells, compare the number and survival rate of Leydig cells separated by four enzyme mass concentrations; observe the Leydig cells and their lipid droplet morphology using hematoxylin-eosin staining and Sudan III staining respectively. Results: The number of isolated interstitial cells in groups A and B was more than that in groups C and D (P<0.05). The survival rates of interstitial cells isolated by the four enzyme mass concentrations were all above 90%, and the difference was not statistically significant (P>0.05). The mesenchymal cells isolated by low concentrations of trypsin (0.05% and 0.125%) were in good growth status, with small and abundant intracellular lipid droplets. After long-term in vitro culture, the cytoplasm became vacuolated and the lipid droplets fused. Conclusion: Low mass concentration of trypsin is effective in isolating primary stromal cells.

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Original research was done by Huang Rui, Zhu Weijie

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Squid Tentacle Peeling Liquid, Enzymatic Hydrolysis, Antioxidant, Degree Of Hydrolysis, Half Inhibitory Concentration

Abstract

Objective: To study the enzymatic hydrolysis process and antioxidant activity of collagen peptides in Peruvian squid tentacle peeling liquid. Method: Using the degree of hydrolysis and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging rate as indicators, single factor experiment and response surface method were used to analyze The enzymatic hydrolysis process was optimized and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (2,2′-azinobis-(3-ethylbenzothiazoline-6) -sulfonic acid) diammonium salt, ABTS) free radicals and? The OH scavenging rate and ferrous iron reducing capacity were used to evaluate the antioxidant activity of the enzymatic hydrolyzate and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and gel exclusion chromatography. Its molecular mass distribution. Results: The optimal enzymatic hydrolysis process was as follows: enzymatic hydrolysis temperature 50 ¡æ, initial pH 7.4, substrate protein mass fraction 3.2%, enzymatic hydrolysis time 3.7 h, and enzyme addition amount 3 000 U/g. Under these conditions, the degree of hydrolysis and the DPPH free radical scavenging rate of the enzymatic hydrolysis product were (37.23¡À0.08)% and (43.61¡À0.09)% respectively. For ABTS+? and? The IC50 of OH scavenging rate were 0.37 mg/mL and 0.41 mg/mL respectively, and showed strong ferrous iron reducing ability; SDS-PAGE showed that under the optimal enzymatic hydrolysis process, the protein was basically hydrolyzed into small molecule peptides; gel Exclusion chromatography analysis showed that the molecular mass of the enzymatic hydrolysis product was between 1 and 5 kD. Conclusion: The enzymatic hydrolysis product has strong antioxidant activity and can be fully developed and utilized as a base material for antioxidant active substances.

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Original research was done by Yu Hui, Wu Yangyang, Sun Haiyan, Jiang Xuhua, Luo Chunyan, Chen Xiao’e

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Grass Carp Skin, Protease, Enzymatic Hydrolysis, Collagen Peptide, Streptococcus Thermophilus

Abstract

Streptococcus thermophilus is considered a multifunctional probiotic. Neutrase 0.8L, Protease P “Amano” 6, ProteAX, Alcalase 2.4LFG and flavor-neutral protease five kinds of grass carp skin protein hydrolyzate were used as a method for cultivating Streptococcus thermophilus. Nitrogen source, using the proliferation effect of hydrolyzate on Streptococcus thermophilus as the evaluation index, select the best hydrolysis enzyme, and use orthogonal experiments to optimize enzymatic hydrolysis conditions. The results show that among the five microbial proteases, Neutrase 0.8L is the best enzyme to hydrolyze grass carp skin protein. The optimal enzymatic hydrolysis conditions are: 1% enzyme amount, 80 min enzymatic hydrolysis time, initial pH 6.5, feed water Ratio 1:2 (m/V). Grass carp skin protein hydrolyzate rich in collagen peptides prepared by Neutrase 0.8L enzymatic hydrolysis method is an ideal nitrogen source for cultivating Streptococcus thermophilus

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Original research was done by Bao Jianqiang, Chen Jiankang

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Bone Substitute Materials, Hydroxyapatite, Collagen Fibers, Elastic Modulus, Image Related

Abstract

Artificial bone replacement material – hydroxyapatite is implanted in the body. As the bone tissue and collagen fibers grow in its pores and the hydroxyapatite degrades, the overall elastic modulus of hydroxyapatite will gradually change. In order to determine the impact of soft tissue on the elastic modulus after implantation in the body, hydroxyapatite samples were implanted under the skin of rats and taken out after 20, 40, 60 and 80 days of implantation, and studied using digital image correlation methods. Effect of fibrous tissue on the elastic modulus of artificial hydroxyapatite. Research results show that the elastic modulus of hydroxyapatite increased significantly when implanted subcutaneously in rats for 20 days, with an increase of 28.83%. After that, the change in elastic modulus became smaller. Analysis suggests that the initial tissue fibers adhere to the micropores of hydroxyapatite and play a reinforcing effect. Afterwards, the reinforcing effect of soft tissue regrown on the surface of the soft tissue will gradually weaken.

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Original research was done by Xu Lianyun, Hou Zhende, Zhao Wei, Bi Ping, Wang Hong

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Diabetes, Cardiomyopathy, Proliferating Cell Nuclear Antigen

Abstract

Objective To explore the therapeutic value and possible mechanism of Tongxinluo on diabetic cardiomyopathy by observing the effect of Tongxinluo on myocardial proliferating cell nuclear antigen (PCNA) in streptozotocin-induced diabetic rats. Methods Among 60 SD rats, 17 were randomly selected as the control group; 40 diabetic rats that were successfully modeled were randomly divided into 4 groups: model 8-week, 12-week group and Tongxinluo treatment 8-week, 12-week group. Each group 10 rats, two groups of Tongxinluo were given Tongxinluo after successful self-modeling. The experiment monitored blood sugar every 4 weeks. At the two experimental end points of 8 weeks and 12 weeks, rat ventricular muscle tissue was taken for immunohistochemistry detection. Proliferating cell nuclear antigen percentage (PCNA%) and myocardial collagen percentage. Results The blood glucose levels of rats in the model group and Tongxinluo treatment group were significantly higher than those in the control group (P0.05); myocardial PCNA% in the 8-week and 12-week model groups increased compared with the control group (P<0.01); Tongxinluo treatment group Myocardial PCNA% in the two treatment groups was significantly reduced compared with the model group at the corresponding time point (P<0.01). At the 8th and 12th weeks of the experiment, the expression of myocardial collagen in the model group was significantly higher than that in the control group (P<0.01). The expression of myocardial collagen in the Tongxinluo treatment group at 8 weeks and 12 weeks was significantly lower than that in the model group at the corresponding time points (P<0.05). Conclusion Tongxinluo can reduce the expression of PCNA and fibrosis in myocardial tissue of diabetic rats. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Zhang Changxi, Ma Li, Xie Chunyi  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Col-¢ñ/Pva Copolymer Spinning, Biocompatibility, Histocompatibility, Fibroblasts, Mice

Abstract

Objective To detect the biocompatibility of type ¢ñ collagen (Col-¢ñ)/polyvinylalcohol (PVA) copolymer spinning. Methods: Mouse fibroblasts (L-929) were used and divided into 100% concentration Col-¢ñ/PVA copolymer spinning extract, 50% concentration Col-¢ñ/PVA copolymer spinning extract, blank control, and positive control. 4 groups, MTT method was used to measure the optical density value of cells in each group on 1, 2, 3, 4, 5, 6, and 7 days, calculate the relative growth rate (RGR) of cells, and determine the level of cytotoxicity; direct contact co-culture L-929 cells, inverted microscope and scanning electron microscope were used to observe the growth of cells on Col-¢ñ/PVA copolymer spinning; Col-¢ñ/PVA copolymer spinning and polyethylene terephthalate (PET) fibers were respectively Implanted under the skin of Kunming mice, specimens were taken at 1, 3, and 9 weeks after surgery to grossly observe the capsule condition, and histological observation was performed using HE and Mallory trichrome methods. Results MTT method: The relative proliferation rates of cells in the two experimental groups at different time points were 90% to 123.61%, and the cytotoxicity rating of Col-¢ñ/PVA copolymer spinning was 0 to ¢ñ level; direct contact method: cells and Col -¢ñ/PVA copolymer spinning direct contact co-culture, growth is good, normal shape, and attached growth. Col-¢ñ/PVA copolymer spinning and PET fibers implanted subcutaneously had capsule formation at 1, 3, and 9 weeks, and the transparency of the capsule increased with time. The inflammatory cells around the capsule were mainly neutrophils, The number of macrophages, lymphocytes, and inflammatory cells decreased significantly over time. Conclusion Col-¢ñ/PVA copolymer spinning has good biocompatibility, and its cytotoxicity and histocompatibility are within the allowable range for clinical application.

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Original research was done by Cai Changbi, Wang Fuyou, Feng Dehong, Chen Jiarong, Xiong Juan, Yang Liu

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Dopamine, Oxidized Sodium Alginate, Collagen, Hydrogel, Adhesive

Abstract

Abstract Using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide/N-hydroxysuccinimide (EDC/NHS) as a catalyst, dopamine was connected to oxidized sodium alginate through amidation reaction On the above, oxidized sodium alginate (COA) containing catechol structure was prepared, and COA was combined with collagen (COL) to prepare a COA-COL hydrogel with adhesive properties. Through ultraviolet-visible spectroscopy (UV-Vis) ), Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (1H NMR) were used to characterize the structure of COA. Scanning electron microscopy, in vitro swelling degradation, universal electronic tensile machine and thiazole blue (MTT) method were used to characterize COA. -The morphology structure, equilibrium swelling rate, degradation rate, adhesive strength and cytotoxicity of COL hydrogel. The research results show that dopamine has been introduced to oxidized sodium alginate, and the substitution degrees are 12.5%, 18% and 22% respectively; A typical sponge porous network structure is formed inside the COA-COL hydrogel. The equilibrium swelling rate first decreases and then increases as the degree of substitution of dopamine increases. The degradation rate decreases with the increase of the degree of substitution. COA- The adhesive strength of COL hydrogel increased from (20.43¡À4.21) kPa without dopamine modification to (29.91¡À6.10) kPa when the dopamine substitution degree was 22%, and it has good biocompatibility.

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Original research was done by Cui Guolian, Dan Nianhua, Dan Weihua

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.