Collagen series

Keywords

Porcine Collagen Membrane, Biocompatibility, Biomaterial, Xenograft, Rat

Abstract

Objective To explore the long-term outcomes of porcine collagen membrane (trade name: sterile biological wound protection membrane) after implantation in rats. Methods Twenty SD rats were randomly divided into two groups, with 10 rats in each group. The rats in the experimental group were subcutaneously implanted with porcine collagen membranes on their backs, while those in the control group were not implanted with porcine collagen membranes. In the experimental group, samples were taken continuously at 3, 7, 15 days and 1, 3, 6, and 12 months after surgery, and gross and histological observation of inflammatory reactions, CD31 immunohistochemical staining to observe neovascularization, and transmission electron microscopy to observe collagen arrangement. ; In the control group, the skin tissue from the same part of the rat’s back was taken for observation and comparison 12 months after surgery. Results The postoperative incision of the rats in the experimental group healed well without obvious redness, swelling and inflammatory reaction. Gross observation showed that as time went by, the porcine collagen membrane was in close contact with the surrounding tissue, without obvious rejection, and the porcine collagen membrane was still clearly identifiable at 12 months. Histological observation showed that infiltration of fibroblasts and inflammatory cells could be seen in the experimental group 7 days after surgery; obvious proliferation of microvessels and fibroblasts could be seen at the connection with the host tissue on 15 days and 1 month, and the inflammatory reaction gradually subsided; 3 months At 6 and 12 months, there are abundant blood vessels and cells around the porcine collagen membrane, and blood vessels and cells can be seen inside; at 6 and 12 months, the proliferation of blood vessels and fibroblasts in the porcine collagen membrane gradually decrease, new collagen increases, and the edges are fused. The number of inflammatory cells in the experimental group at 15 days and 1 month after surgery was significantly higher than that in the control group at 12 months after surgery (P<0.05); compared with the control group at 12 months, the difference was not statistically significant (P>0.05). CD31 immunohistochemistry staining showed that intramembranous angiogenesis was visible in the experimental group 15 days after surgery, intramembranous and extramembranous angiogenesis was obvious at 1 month, and angiogenesis was significantly reduced at 12 months. Compared with the control group, the positive expression of CD31 in the experimental group was significantly reduced 15 days and 12 months after surgery, and the positive expression of CD31 was significantly increased 1 month after surgery, and the differences were statistically significant (P<0.05). Transmission electron microscopy showed that the collagen arrangement of the grafts in the experimental group did not change significantly 12 months after surgery compared with before implantation, and pericytes and fibroblasts were visible inside. Conclusion: The long-term structure of porcine collagen membrane after implantation in rats is stable and has good immune tolerance properties. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Ye Ziqing, Wang Hui, Xie Weiguo, Zhao Chaoli  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Tio2 Collagen, Infrared Emissivity

Abstract

A new type of organic-inorganic composite material was obtained by composited with collagen and modified nano-TiO2. The changes of collagen content in the composite with composite temperature and pH were studied. TiO2 crystal form, Al2O3 coating modification and glutaraldehyde cross-linking modification were also investigated. Effect of properties on infrared emissivity of composite materials. The results show that the optimal temperature for composite of collagen and modified nano-TiO2 is 50¡æ, pH is 8.0, and the collagen content can reach up to 9.45wt%. The strong composite synergy between the two significantly reduces the infrared emission of the material. efficiency, and improves the thermal stability of the material; after the composite material is cross-linked and modified with glutaraldehyde, it can form a tight and orderly network layered structure, the thermal stability is further improved, and the infrared emissivity can be reduced to a minimum of 0.502.

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Original research was done by SUN Yan-Qing,ZHOU Yu-Ming, Sun Yanqing, Zhou Yuming

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Chronic Aluminum Exposure, Rat, Bone And Cartilage Injury, Collagen Pathway, Dynamic Analysis

Abstract

In order to explore the mechanism of collagen pathways and collagen metabolism levels in bone and cartilage damage caused by chronic aluminum exposure in rats, 100 4-week-old clean-grade Wistar rats were randomly divided into an aluminum-dyed group (430 mg¡¤L-1Al3+) and a control group ( Distilled water), dye aluminum through drinking water, kill 10 aluminum-dyed rats and control rats every 30 days, set up 5 observation points, the longest aluminum dyeing time is 150 days. At the same time, use an electronic scale to weigh the rats every 30 days 1 times; flame atomic absorption spectrophotometry was used to determine the aluminum content in serum, bone and cartilage; solid-phase sandwich ELISA was used to detect type ¢ñ procollagen carboxy-terminal propeptide (PICP) and type ¢ñ collagen C-terminal peptide (CTX-¢ñ) in serum. ), type ¢ò collagen (collagen ¢ò) and type ¢ò collagen C-terminal peptide (CTX-¢ò) content. The results showed that the rat aluminum poisoning model was successfully replicated; with the extension of aluminum exposure time, the body weight of rats in the aluminum-dyed group increased. After 60 days, it was significantly lower than that of the control group (p<0.01); the aluminum content in serum, bone and cartilage of the aluminum-stained group gradually increased and was significantly higher than that of the control group (p<0.01); the synthesis of PICP and type II collagen showed a gradual downward trend. , and were significantly lower than those in the control group (p<0.05, p<0.01); the CTX-¢ñ and CTX-¢ò contents continued to remain at high levels, and were significantly higher than those in the control group after 90 and 60 days of aluminum exposure respectively (p<0.01). This shows that long-term aluminum exposure can cause aluminum to accumulate in bones and cartilage, reduce structural collagen in bones and cartilage, and cause bone and cartilage damage. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Li Xinwei, Zhang Lichao, Hu Chongwei, Gu Qingyun, Li Yanfei  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Chemokine Cxcl12, Simvastatin, Collagen, Osteogenesis

Abstract

Purpose: To explore the use of mouse stromal cell-derived factor 1 (msdf-1) combined with simvastatin (sim) and collagen scaffold (bio-oss?) to construct tissue-engineered bone without external seed cells. feasibility, and to test its effect on ectopic osteogenesis in vivo. Methods: 32 icr mice were randomly divided into 4 groups, with 8 mice in each group. Skin incisions were made on the skulls of mice, and mice in each group were implanted with: (1) 1:50 (volume ratio) dimethyl Sulfoxide (dimethylsulfoxide, DMSO)/phosphate buffered saline (PBS) mixture + collagen scaffold (blank control group); (2) 10-3mol/lsim solution + collagen scaffold (SIM group); ( 3) 200mg/lmsdf-1 solution + collagen scaffold (msdf-1 group); (4) 10-3mol/lsim + 200mg/lmsdf-1 solution + collagen scaffold (sim+msdf-1 group). One week after implantation, 50 ¦Ìl of the corresponding solutions of each group above were locally injected into the stent for 2 consecutive days every day. After 6 weeks of feeding, the scaffold and surrounding tissues were removed, and the osteogenic effect was qualitatively and quantitatively observed through soft X-ray projection imaging, gray scale measurement, He staining, and immunohistochemical staining. Results: The soft , p<0.01] and msdf-1 group [(255529.5¡À152142.4) pixels, p<0.05]; obvious expression of osteopontin and osteocalcin can be seen in the sim+msdf-1 group; sim+msdf-1 group The density of vascular plexus [(46¡À8) strips/mm2] was significantly higher than that of the blank control group [(23¡À7) strips/mm2, p<0.01] and sim group [(24¡À6) strips/mm2, p<0.01] . Conclusion: Tissue-engineered bone without external seed cells constructed using msdf-1 combined with SIM and collagen scaffold can ectopically form bone in the mouse skull subcutaneously. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Ou Mengen,*, Zhang Xiao*, Liu Yunsong, Ge Yanjun, Zhou Yongsheng  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Konjac Glucomannan Microspheres, Collagen, Dual-Action Microcarriers, Cell Culture

Abstract

Using konjac glucomannan microspheres as the matrix, the microspheres were aminated with 2-diethylaminoethane hydrochloride (DEAE), activated with 1,4-butanediol diglycidyl ether, and the collagen was The protein was coated on the microspheres and then cross-linked with glutaraldehyde to obtain uniformly coated and stable charge-collagen dual-action microcarriers. The collagen coating conditions and activation methods, collagen from different sources, and the amount of DEAE were investigated. On the effect of microcarrier cell culture, the culture of Vero cells on microcarriers was studied. The results showed that the collagen layer of charge-collagen dual-action microcarriers was controllable in the range of 5~50mm, and the adhesion of cells after 2 hours of culture was The amount is about 4¡Á104mL-1, which is between Cytodex1 and Cydodex3. After 96h, the growth rate of cells on the microcarrier gradually exceeds that of the charge-type microcarrier Cydodex1. At 144h, the number of cells is greater than that of Cydodex1 and Cydodex3, reaching 1.59¡Á106mL-1.

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Original research was done by Wang Shaojiu, Wang Qibao, Li Juan, Ma Guanghui, Zhou Weiqing

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

? , Channel Catfish, Fish Skin, Collagen, Extractant, Amino Acid, Viscosity, Denaturation Temperature

Abstract

Different extraction agents were selected to prepare channel catfish skin collagen, and some qualitative studies were conducted on the collagen. Experimental results show that under 4¡ãC conditions, catfish skin is soaked in 0.1 mol/l naoh for 6 hours and then in 2.5% nacl for 6 hours. It can remove impurity proteins better than using naoh and nacl alone or at the same time. Using 10% isopropyl Propanol solution removes fat, and leaching with 0.1mol/l citric acid for 3 days can better extract collagen, which is colorless and odorless, and the extraction rate can reach 34.67%. The obtained collagen is rich in glycine, with a mass fraction of 21.19%, and its denaturation temperature is 50.2¡ãC. The sds-page experimental results show that the extracted catfish skin acid-soluble collagen has high purity, contains two ¦Á chains, and has a higher ¦Â chain content. Fish skin collagen solution has high viscosity, which increases with the increase of protein concentration.

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Original research was done by Wu Ti, Chen Shunsheng

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Pork Skin, Alcalase, Collagen Hydrolyzate, Degree Of Hydrolysis, Antioxidant Properties

Abstract

Using fresh pig skin as raw material, Alcalase was used to hydrolyze collagen, and various factors affecting the Alcalase hydrolysis process were studied. By measuring the degree of hydrolysis and superoxide anion radical (O2-¡¤) scavenging rate, the Alcalase hydrolyzed pig skin was determined. Optimal conditions for collagen; study the scavenging effects of DPPH free radicals and O2-¡¤ on pig skin collagen hydrolyzate of different mass concentrations prepared under optimal conditions. The results show that the optimal conditions for Alcalase to hydrolyze pig skin collagen are: pH 7.5, temperature 55¡ãC, enzyme to substrate ratio 6000U/g, substrate mass concentration 40mg/mL, and hydrolysis time 4h; under these hydrolysis conditions, The degree of hydrolysis reaches 9.55%, and the O2- ¡¤ scavenging rate reaches 60.11%; within the corresponding mass concentration range of 10 to 50 mg/mL, the maximum scavenging rate of DPPH free radicals of the pig skin collagen hydrolyzate is 95.06%, and the IC50 is 3.89 mg/mL. ;O2-¡¤Maximum clearance rate is 65.89%, IC50 is 16.43mg/mL. Pig skin collagen hydrolyzate has strong free radical scavenging ability

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Original research was done by Fu Gang, Yu Xia, Li Hua, Li Cheng, Chen Daiwen

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Collagen, Tissue Engineered Skin, Scaffold, Cells, Blood Vessels

Abstract

Collagen-based composite tissue-engineered skin is the future development direction and research hotspot. Based on the introduction of tissue-engineered skin, this article briefly reviews and discusses the principles and methods of collagen modification, the pore-making method of collagen-based composite scaffold materials and its relationship with the pore structure, the selection of seed cells, and cell structure. Key scientific and technical issues such as composite culture with scaffold materials, vascularization and its influencing factors, and the regeneration of other skin appendage organs are also clarified, and the ideas and methods for solving these scientific and technical problems are clarified, providing useful information for the research and development of tissue-engineered skin. reference

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Original research was done by Dan Weihua, Dan Nianhua, Liu Ting

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

The Mechanism Of Action Of Zixue Powder In The Treatment Of Collagen-Induced Arthritis

Abstract

Objective To study the therapeutic effect and mechanism of Zixue Powder on collagen-induced arthritis in rats. Methods Wistar rats were randomly divided into 5 groups, namely control group, model group, indomethacin tablets (2 mg/kg) group, and Zixue powder 0.5 and 1.0 g/kg groups, with 10 rats in each group. Establish a rat type ¢ò collagen-induced arthritis model. Rats were administered intragastrically on the 12th day after the initial immunization, with a dosage of 10 mL/kg, once a day. Both the control group and the model group were given the same volume of normal saline by gavage. Each group continued to be administered for 3 weeks. The width, thickness and circumference of the left hind ankle of the rats were measured, and the arthritis index was calculated. Observe the pathology of rat ankle joints. The serum inflammatory factor platelet-activating factor (PAF) level, cyclooxygenase-2 (COX-2) activity, and tumor necrosis factor ¦Á (TNF-¦Á) levels were measured using ELISA, and serum circulating immune complexes ( CIC) level. Results After 7 days of administration, the ankle joint width and thickness of the Zixue Powder group were significantly lower than those of the model group, and this continued until the 21st day of administration. Synovial cell hyperplasia and synovial tissue congestion and edema were significantly reduced in the Zixue Powder group. Compared with the model group, the systemic performance score, joint swelling index and arthritis index of the Zixue Powder group were significantly reduced (P<0.05, 0.01, 0.001). Compared with the model group, the serum PAF level and COX-2 activity in the Zixue Powder 0.5 and 1.0 g/kg groups were significantly reduced (P<0.001). Compared with the model group, the serum TNF-¦Á and CIC levels in the Zixue Powder 0.5 and 1.0 g/kg groups were significantly reduced (P<0.05, 0.01, 0.001). Conclusion Zixue Powder has a therapeutic effect on collagen-induced arthritis damage in rats, and its mechanism may be related to the anti-inflammatory and antioxidant effects of Zixue Powder For further information of this article and research, feel free to contact our team for asssitance. Original research was done by 10.7501/j.issn.1674-5515.2016.08.003  

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.

Keywords

Pachydermodactyly, Collagen Deposition, Children Pachydermodactyly, Collagen Deposition, Children

Abstract

Objective: To explore the clinical characteristics of periproximal interphalangeal joint collagenosis (pachydermodactyly, PDD) and improve understanding of the disease. Methods: The clinical data of 2 children diagnosed with PDD were summarized and analyzed, and relevant literature was reviewed. Results: Both children showed swelling of the proximal interphalangeal joints of both hands without joint pain; physical examination showed fusiform enlargement of the sides of the affected joints, normal skin color and skin temperature, and no tenderness; there were no inflammatory indicators or immunological examinations. Abnormality; imaging examination showed swelling of the soft tissues of the proximal interphalangeal joints of both hands, without abnormal joint or bone changes; skin histopathological examination showed mild hyperplasia of squamous epithelium with hyperkeratosis, and hyperplasia of interstitial fibrocollagen tissue, and was diagnosed as PDD. , without treatment, all were followed up for more than 3 months, and there was no progression of joint symptoms. Conclusion: PDD is a rare benign disease that usually does not require special treatment. It needs to be clinically differentiated from inflammatory arthritis to avoid misdiagnosis and mistreatment. Objective: To explore the clinical features of pachydermodactyly (PDD) and to improve the under-standing of PDD. Methods: Summarize and analyze the clinical data of 2 cases of PDD and review relevant literature. Results: Both patients showed swelling of proximal interphalangeal joints of both hands without arthralgia. Physical examination showed fusiform enlargement of the lateral surface of the involved joint, normal skin color and temperature, no tenderness; inflammatory in-dex and immunological examination were normal; imaging examination showed swelling of the soft tissue of the proximal interphalangeal joints of both hands, without abnormal changes of joints and bones. Histopathological examination of the skin showed mild hyperplasia of squamous epithelium with hyperkeratosis and interstitial fibrous collagen hyperplasia, which was diagnosed as PDD. No treatment was given. All patients were followed up for more than 3 months, and the joint symptoms did not progress. Conclusion: PDD is a rare benign disease, usually without special treatment, clini-cal and inflammatory arthritis should be differentiated to avoid misdiagnosis and mistreatment.

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Original research was done by Chen Yu, Jiang Zhong, Shao Shihong, Chang Hong, Shao Leping, Lin Yi

About ETChem

ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.

ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.

As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.