Therapeutic Effect Of Deer Antler Exfoliated Collagen On Rats With Osteoporosis Caused By Ovariectomy
Keywords
Collagen From Deer Antlers, Osteoporosis, Ovariectomized Rats
Abstract
Objective To study the therapeutic effect of deer antler exfoliated collagen on osteoporosis in ovariectomized rats. Methods Wistar rats, ¡â, were randomly divided into 6 groups: sham operation group, model control group, positive control group and antler exfoliation collagen high, medium and low dose groups. The osteoporosis model was established by removing both ovaries. Administration was started 7 days after operation and continued for 90 days. The bone density, serum alkaline phosphatase (ALP) activity and hydroxyproline (Hyp) content of rats were detected. , bone tissue morphometric parameters, bone mechanics, body weight and organ coefficients, etc. Results Compared with the model control group, after treatment with deer antler collagen, the bone density of rats significantly increased, serum ALP activity decreased, Hyp content increased, and bone histomorphometry parameters and bone mechanical indicators were significantly improved. Body weight and organ coefficients had no significant effects. Conclusion Deer antler exfoliated collagen has a certain therapeutic effect on rats with osteoporosis caused by ovariectomy.
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Original research was done by Zhang He, Xu Yunfeng, Lin Yanling, Niu Fang, Zhao Yu
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