Effect Of Collagen Mimetic Peptides On L929 Cell Adhesion
Keywords
Collagen Mimetic Peptide, Collagen, Cell Adhesion, L929 Cells
Abstract
Three types of collagen mimetic polypeptides (CMPs) that simulate collagen triple helical structures or/and integrin recognition sites were designed and synthesized, and their in vitro cytocompatibility was evaluated to study their effects on the growth and adhesion of mouse fibroblasts (L929). Attached influence. Experiments have confirmed that the three CMPs have no obvious cytotoxic response to the growth of fibroblasts; the three substrates coated with collagen-mimicking polypeptides can promote cell adhesion and growth to a certain extent, and have good cell adhesion rate and cell adhesion. CMP27, which contains a triple helix structure and an integrin recognition site, has a better adhesion-promoting effect, and the number and shape of cell adhesion are close to those of collagen. Preliminary research results confirm that the collagen triple helix structure and integrin recognition site work together to promote L929 cell adhesion. Therefore, CMP can effectively promote cell adhesion and is expected to be used as an adhesive agent in the biomedical field. This study can provide new research ideas for the design of peptide-based bioactive materials.
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Original research was done by Liu Lingling, Zhang Qiqing, Wang Jingjie, Chen Huijuan
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