Effects Of Hydrogen Sulfide On Myocardial Fibrosis And Expression Of Nf-¦ªbp65 And Tnf-¦¡ In Diabetic Rats
Keywords
Hydrogen Sulfide, Diabetes, Cardiac Remodeling, Nf-&Kappa, Bp, Tnf-&Alpha, Type Iv Collagen
Abstract
Objective To explore the effect of gas signaling molecule hydrogen sulfide (H2S) on myocardial fibrosis and the expression of TNF-¦Á and NF-¦ÊBp65 in diabetic rats. Methods Thirty male adult SD rats were divided into 3 groups: control group (Control group), diabetic rat group (STZ group), and hydrogen sulfide intervention diabetic rat group (STZ+H2S group), with 10 rats in each group. The diabetes model was established by intraperitoneal injection of streptozotocin (STZ, 40 mg/kg); the Control group was intraperitoneally injected with normal saline every day; the STZ+H2S group was intraperitoneally injected with sodium hydrosulfide (H2S donor) solution (100 ¦Ìmol/kg) every day, 8 The rats were sacrificed after 1 week, and HE staining was used to observe myocardial histopathological changes; Western blot was used to detect the expression of type IV collagen, NF-¦ÊBp65 and TNF-¦Á. Results Compared with the STZ group, the interstitial fibrosis of cardiomyocytes after H2S intervention was significantly improved, and compared with the Control group, the expression of type IV collagen and TNF-¦Á and NF-¦ÊBp65 proteins in the STZ group was significantly increased (P<0.05 ); compared with the STZ group, the expression of type IV collagen, TNF-¦Á and NF-¦ÊBp65 proteins in the STZ+H2S group was significantly reduced (P<0.05). Conclusion H2S improves myocardial fibrosis in diabetic rats, and inhibiting the NF-¦ÊB/TNF-¦Á signaling pathway is one of its possible mechanisms. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Wu Zhixiong, Luo Jian, Li Fang, Xiao Ting, Zhou Songbai, Yang Jun
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