Experimental Study On Bme-10X Type Collagen/Hydroxyapatite Artificial Bone Guiding Periodontal Tissue Regeneration In Beagle Dogs
Keywords
Periodontal Disease, Tissue Regeneration, Collagen/Hydroxyapatite Artificial Bone
Abstract
Objective To evaluate the ability of BME-10X type collagen/hydroxyapatite artificial bone to guide periodontal tissue regeneration in beagle dogs. Methods Four 18-month-old male beagle dogs were selected for basic periodontal treatment. One week after the basic treatment, the 3rd and 4th mandibular premolars and the same-named teeth on the opposite side of the same jaw were randomly selected into the experimental group or the control group to create periodontal defects. The experimental group was implanted with BME-10X collagen/hydroxyapatite artificial artificial teeth. Bone, and no material was implanted in the control group. The animals were sacrificed 12 weeks after surgery and histopathological analysis was performed. Results Compared with the control group, the experimental group achieved more tissue regeneration. The heights of the new alveolar bone in the experimental group and the control group were (3.01¡À0.14) and (1.32¡À0.11) mm respectively. The difference between the two was statistically significant. significance (P<0.05). The heights of the new periodontal ligament tissue in the experimental group and the control group were (3.12¡À0.19) and (1.35¡À0.12) mm respectively, and the difference between the two was statistically significant (P<0.05). The heights of new cementum in the experimental group and the control group were (3.30¡À0.15) and (2.70¡À0.12) mm respectively, and there was no statistical significance between the two (P>0.05). The periodontal ligament fibers of the new periodontal tissue penetrate deep into the new bone tissue and cementum, and their structural characteristics are not significantly different from those in the physiological state. Conclusion BME-10X type collagen/hydroxyapatite artificial bone material has strong ability to induce periodontal tissue regeneration.
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Original research was done by Chen Bin, Wu Wenlei, Zhang Qiqing, Huang Xiaofeng, Chen Xianghua
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