Formation Of Collagen Fibrils In Vitro Of Rat Cartilage Type Ii Collagen
Keywords
Fibril Formation, Type Ii Collagen, Cartilage
Abstract
The extraction and purification method of type II collagen was established, and the kinetics of collagen fibril formation, stability and ultrastructure of collagen fibrils of rat cartilage type II collagen in vitro were observed. The results show that the resting phase and growth phase of type II collagen are 15 and 120 minutes respectively, the gelation rate in the growth phase is 0.0060, and the gel resiliency is 13.58%. The collagen fibrils show a typical natural fiber structure with 64nm periodic striations, but The fiber diameter increases compared to the body. These are of great significance for studying the formation process and regulatory mechanism of collagen fibrils in vivo.
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Original research was done by Fu Zhihou, Zhang Yanyuan
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