Meta-Analysis Of The Diagnostic Value Of Bone Metabolism Index Ictp In Lung Cancer Bone Metastasis
Keywords
Type I Collagen Pyridine Cross-Linked Terminal Peptide, Lung Cancer, Bone Metastasis, Diagnostic Value, Meta Analysis, Systematic Review
Abstract
Objective To systematically evaluate the diagnostic value of bone metabolism index cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) in lung cancer bone metastasis. Methods A computer search was performed on The Cochrane Library, PubMed, EMbase, WanFang Data and CBM database to collect relevant studies on ICTP diagnosis of lung cancer bone metastasis. The search time limit was from the establishment of the database to November 2017. Two researchers independently screened the literature, extracted data, and used the QUADAS-2 tool to evaluate the risk of bias of the included studies, and then used Meta-Disc 1.4 software to conduct a meta-analysis. Results A total of 8 studies were included, including 781 patients. Meta-analysis results show that the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under the SROC curve of ICTP in diagnosing lung cancer bone metastasis are 71% respectively [95% CI (0.65, 0.76)] , 80% [95%CI (0.76, 0.84)], 3.79 [95%CI (2.31, 6.21)], 0.35 [95%CI (0.25, 0.49)], 14.67 [95%CI (6.99, 30.81)] and 0.860 3. Conclusion ICTP has certain diagnostic value for bone metastasis of lung cancer, and it can be helpful for diagnosis in conjunction with bone scan and other imaging methods. Due to limitations in the quantity and quality of included studies, more studies are needed to confirm the above conclusions.
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Original research was done by Yu Xijie, Zhao Qian
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