Molecular Mechanism Of Rapid Gelatinization Of Rabbit Skin Collagen
Keywords
Collagen, Gelatin, Structural Changes, Molecular Simulation, Mechanism
Abstract
YASARA software was used to perform kinetic simulation of the acid-induced gelatinization process of rabbit skin collagen, and analyze the molecular mechanism of rapid gelatinization of rabbit skin collagen. The root mean square deviation results showed that acid treatment separated the subunit components of the non-helical region of collagen molecules, but had little effect on the conformation of individual subunits. In the early stage of acid treatment, the hydrogen bonds in the triple helix region of rabbit skin collagen were rapidly destroyed in a short period of time. After 50 ns of simulation, the number of hydrogen bonds remained relatively stable, which was consistent with the actual research results. The triple helical structure is accompanied by the destruction of hydrogen bonds and transforms into other secondary structures in the early stage of acid treatment. As the simulation time increases, the sum of the relative contents of ¦Á-helices and ¦Â-sheets first increases and then decreases. The degree of gelatinization is optimal when the sum of the relative contents of ¦Á-helices and ¦Â-sheets reaches the maximum.
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Original research was done by Yu Yong, Feng Xin, Zhou Hongyuan, Zhang Yuhao, Dai Hongjie, Su Xianbo, Guo Ting, Ma Mingsi, Ma Liang
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