Non-Collagen Mimetic Peptide E8Ds Promotes Type I Collagen Biomimetic Mineralization
Keywords
Organic Polymer Materials, Biomineralization, Non-Collagen, Collagen Fibers, Polypeptides
Abstract
By analyzing the functional domains of bone sialoprotein and dentin matrix protein, a non-collagen mimetic peptide e8ds (eeeeeeedsesseedr) was designed and synthesized, and the collagen biomimetic mineralization system was introduced to jointly regulate the mineralization process of calcium phosphate crystals. Circular dichroism spectroscopy and infrared spectrum analysis results show that the peptide e8ds can combine with calcium ions and collagen molecules through electrostatic interaction. The analysis results of the peptide e8ds using a steady-state gel system showed that e8ds has a strong ability to regulate calcium and phosphate mineralization. The addition of peptides helps the molecular assembly of collagen fibers, increases nucleation sites, promotes the mineralization of calcium phosphate on the surface of collagen fibers, and significantly improves the degree of mineralization of collagen fibers.
For further information of this article and research, feel free to contact our team for asssitance.
Original research was done by Wang Xiumei, Wang Qiong, Cheng Zhenjiang, Cui Fuzhai
About ETChem
ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.
ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.