Preparation And Osteoinduction Capacity Of Collagen/Bone Morphogenetic Protein Composites Preparation And Osteogenic Properties Of Collagen/Bmp Composites
Keywords
Collagen, Bone Morphogenetic Protein-2, Bmp-2, Bone Defect, Ectopic Bone Formation Collagen, Bone Morphogenetic Protein-2, Ectopic Osteogenesis, Bone Defect
Abstract
Collagen/bone morphogenetic protein composites were prepared with collagen type I sponge and bone morphogenetic protein-2 (BMP-2). The composites were implanted into Latissimus dorsi muscles pouches of rabbits. Samples were studied with ALP staining, Von Kossa staining, HE staining , toluidine blue staining and CD31 histochemical labeling of microvessel. Bony samples were then used to repair mandibular defect. The effects were evaluated by X-ray, compressive strength, economycin fluorescence labeling, HE staining, toluidine blue staining and bone quantity analysis. Bone formation induced by collagen/BMP composites was found as woven bone between 4 and 6 weeks; cartilaginous osteogenesis was the main type of bone formation; microvessels could be seen in the bony tissues; and the bone defects were healed completely 6 weeks after operation. Bone formation induced by collagen/BMP composites in the muscles can be used as a donor to repair the bone defect.
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Original research was done by Weiqiang Tan,Jinghong Xu,Youshan Liu,Jun Lin,Huiming Wang, Tan Weiqiang, Xu Jinghong, Liu Youshan, Lin Jun, Wang Huiming
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