Preparation Of Multifunctional Dressings With Core-Shell Fiber Structure By Coaxial Electrospinning Method
Keywords
Coaxial Electrospinning, Multifunctional Dressing, Collagen, In Vitro Antibacterial, Cell Adhesion
Abstract
Abstract An uncross-linked dressing with core-shell structure nanofibers was prepared by coaxial electrospinning. The core of the fiber is polycaprolactone (PCL) loaded with the antibacterial drug mupirocin, and the outer shell is made of polycaprolactone (PCL) loaded with the anesthetic lidocal. Cross-linked dressing was obtained by cross-linking the collagen shell with genipin. The surface morphology of the uncross-linked dressing and the core-shell structure of the fiber were observed with scanning electron microscope (SEM) and transmission electron microscope (TEM). .The results of the in vitro drug release experiment showed that in the two dressings, both drugs showed burst release within 1 hour, and in the subsequent 60 hours, both drugs were slowly released from the dressing, indicating that 2 All these dressings have good sustained analgesic and antibacterial properties. Bicinchonininc acid (BCA) protein test results show that the collagen on the outer shell of the uncross-linked dressing can be continuously released. In vitro cell culture results show that with cross-linked dressings, Compared with cross-linked dressings, uncross-linked dressings can better promote the adhesion and growth of fibroblast L929 cells and have a better effect on promoting wound healing. In vitro antibacterial test results show that the antibacterial properties of the two dressings loaded with mupirocin The performance was significantly higher than that of the control group and had good antibacterial properties.
For further information of this article and research, feel free to contact our team for asssitance.
Original research was done by Chen Lamei, Cao Jie, Ye Lin, Zhang Aiying, Feng Zengguo
About ETChem
ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.
ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.
