Protective Effect And Mechanism Of Cod Skin Collagen Peptide On Gastric Mucosal Damage In Rats
Keywords
Collagen Peptide, Gastric Mucosa, Preventive Effect, Alcohol Induction, Mechanism
Abstract
Objective: To explore the protective effects and related mechanisms of cod skin collagen peptides with different molecular weight segments on alcohol-induced gastric mucosal injury. Methods: Collagen was extracted from cod skin and enzymatically hydrolyzed with complex enzymes to prepare collagen peptides of different molecular weight segments. A rat acute gastric mucosal injury model induced by high volume fraction of alcohol was used to observe and analyze the degree of gastric mucosal damage and analyze the gastric tissue. and serum physiological and biochemical indicators were tested. Results: Compared with the model group, collagen peptides could reduce hemorrhagic damage of gastric glands in rats, reduce Ca2+ content and myeloperoxidase activity in gastric tissue (P<0.05); among them, medium molecular weight collagen peptides had the best effect. The gastric mucosal damage index of rats in the group dropped to 9.21% (P£¼0.01), and the damage inhibition rate was 57.16%; collagen peptides can increase the glycoprotein content in gastric tissue (P£¼0.05), reduce the malondialdehyde content in gastric tissue, and improve Gastric tissue superoxide dismutase activity and serum glutathione content (P<0.05). Conclusion: Collagen peptides can protect against acute gastric mucosal injury by enhancing the gastric mucosal barrier and the body's anti-free radical oxidation level in rats. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Hou Hu, Ni Xin, Jiang Huiming, Li Bafang, Bu Lin, Wang Zhicong
About ETChem
ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.
ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.
