Study On Collagen Degradation In Hypertrophic Scars
Keywords
Hypertrophic Scar, Collagen, Degradation
Abstract
Abstract: Objective: To study the relative relationship between collagen accumulation and removal in hypertrophic scars. Methods: Experimental methods include clinical observation, animal models and cell culture. Observation methods include: light microscopy and electron microscopy, histochemistry, in situ hybridization, dot hybridization, etc. Results: ¢Ù The natural formation of hypertrophic scars is very slow, but drug intervention can make them disappear by 1/3 to 2/3 within a month. ¢Ú The collagen synthesis rate in hypertrophic scars increases, but its degradation rate slows down more significantly. ¢ÛThe expression of collagenase increases in hypertrophic scars, but its actual production and activity decrease. ¢ÜCh-4-S is significantly increased in hypertrophic scars. On the one hand, it surrounds collagen fibers and hinders the contact and degradation of collagenase. On the other hand, it also reduces the activity of collagenase through TIMP. ¢Ý TIMP increases in hypertrophic scars and reduces collagenase activity. ¢Þ TGB-¦Â is significantly increased in hypertrophic scars, and its expression is positively correlated with TIMP expression and negatively correlated with the number of apoptotic cells. TGF-¦Â reduces the expression and activity of MMP-1. ¢ß The vast majority of fibroblasts in hypertrophic scars are myofibroblasts. There is very little apoptosis in the proliferation stage and a significant increase in the mature stage. Conclusion: ¢Ù The apoptosis of fibroblasts in hypertrophic scars is slowed down and the number and activity of collagenase are reduced. Collagen is surrounded by Ch-4-S and its degradation is slowed down, resulting in collagen accumulation, which is the main aspect of hypertrophic scar formation. ¢ÚAccelerating cell apoptosis and collagen degradation may be an easier and faster way to prevent and treat hypertrophic scars
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Original research was done by Wu Zongyao; Wu Jixiang; Liu Hongliang; Wang Qin; Yin Qing; Wang Dehuai
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