Study On The Effect Of Ligustrum Lucidum Water Extract On Bone Structure And Bone Metabolism In Ovariectomized Rats
Keywords
Ligustrum Lucidum Osteoporosis Calcium And Phosphorus Metabolism Collagen Metabolism Bone Structure
Abstract
Objective To explore the effect of Ligustrum lucidum water extract on bone protection and bone metabolism regulation in osteoporosis rats. Methods Ovariectomy was used to create a rat osteoporosis model. In the sham operation group, only the fat around the ovaries that was the same size as the ovaries was removed. The experiment was divided into 4 groups: sham operation group, model group, alendronate sodium (0.12 g/kg) group, and Ligustrum lucidum water extract (3.5 g/kg) group, with 9 animals in each group. Each group was administered ig for 12 consecutive weeks. At the end of the experiment, serum calcium (S-Ca), serum phosphorus (SP), urinary calcium (U-Ca/Cr), urinary phosphorus (UP/Cr) and serum high-density lipoprotein cholesterol (HDL-C) were measured using biochemical methods. ), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triacylglycerol (TG); serum type I collagen amino-terminal propeptide (PINP) and type I collagen carboxyl-terminal peptide were measured using ELISA (CTX-I), osteocalcin (OCN) and urinary deoxypyridine (DPD); the activity of serum alkaline phosphatase (ALP) was measured by radioimmunoassay; evaluated by bone densitometer, VivaCT and universal testing machine respectively Structural changes in bone tissue. Results Ligustrum lucidum water extract can significantly inhibit the increase in body weight of rats caused by ovariectomy, increase the levels of S-Ca, SP, HDL-C and PINP, and reduce the levels of U-Ca/Cr and UP/Cr in ovariectomized rats. , reducing the levels of LDL-C, TC, TG, ALP, OCN and CTX-I in serum and the amount of DPD in urine (P<0.05, 0.01). Ligustrum lucidum water extract can increase the bone mineral density (BMD) of the femur and vertebrae in ovariectomized rats, improve the microstructure of the femur, and increase bone strength. Conclusion Ligustrum lucidum aqueous extract can increase BMD and bone strength in ovariectomized rats, and its mechanism of action is related to the regulation of calcium and phosphorus metabolism, collagen and non-collagen protein metabolism. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Liu Haixia, Tang Yuqing, Zhang Dongwei, Zhu Ruyuan, Li, Yang Meijuan, Liu Chenh, Niu Jianzhao, Wang Lili, Wang Liang, Mo Fangfang, Zhao Dandan, Guo Yubo, Ma Rufeng, Gao Sihua
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