The Calcium Absorption-Promoting Effect Of Crucian Carp Skin Collagen Peptide On Mice
Keywords
Crucian Carp Skin, Collagen Peptide, Calcium Absorption, Low Calcium Dietary Model, Bone Microstructure
Abstract
Objective: To study the calcium absorption-promoting effect of collagen peptides (CPs) in mice. Methods: The mouse low-calcium dietary model method was adopted, Kunming male mice were used as experimental animals, and a normal group, a low-calcium model group, a calcium carbonate group, a low-dose CPs (500 mg/kg mb+CaCO3), and a high-dose (1 000 mg /kg mb£«CaCO3) group and casein phosphopeptide control group were administered orally continuously for 6 weeks to examine the serum calcium, phosphorus, alkaline phosphatase (ALP) activity, calcium absorption rate, various bone indicators and bone microscopic Structural and trabecular bone morphological changes. Results: The ALP activity of mice in CPs low- and high-dose groups was significantly lower than that of the low-calcium model group (P<0.05). The bone length, dry mass index, bone calcium content, bone mineral density (BMD), bone The mineral content (bone mineral content, BMC) was significantly higher than that of the low-calcium model group (P<0.05). The CPs low-dose group could make the various indicators of mice fed low-calcium feed reach the level of the normal group of mice. The ALP activity of mice in the CPs low-dose group was significantly lower than that of the calcium carbonate group (P<0.05), and their bone calcium content, BMD, and BMC were all significantly higher than those of the calcium carbonate group (P<0.05), suggesting that CPs should be supplemented while supplementing calcium carbonate. , which has a better calcium absorption effect. Conclusion: CPs can increase the calcium absorption rate in mice, increase the number and strength of bone trabeculae, and promote bone growth, thereby effectively promoting calcium absorption. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by He Hui, Hou Tao, Liu Weiwei, Liu Yanshuang, Shi Wen, Guo Danjun
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