The Photodynamic Effect Of Rhodopsin B Regulates The Pyridinoline Cross-Linking Content In Collagen: A Preliminary Study On The Mechanism Of Photodynamic Therapy For Fibrosis
Keywords
Aphrodisin B, Photodynamic Effect, Collagen, Pyridinoline Cross-Linking, Fibrosis
Abstract
One of the typical characteristics of fibrosis is an abnormal increase in the content of pyridinoline cross-linked collagen in the fibrotic tissue, which is not easily biodegradable. Due to the accumulation of collagen that leads to fibrosis, the pyridinoline cross-linked content is abnormally increased. High photosensitivity can also be used as an important marker for diagnosing organ fibrosis. Aphrodisin B is a natural photosensitizer produced in my country. It has high photodynamic activity against tumors, viruses and microvascular diseases, and has low dark toxicity and rapid tissue metabolism. and other advantages. This article studies the photodynamic treatment of fibrosis with rhodophyllum at the molecular level, proving that gelatin has a pyridinoline cross-linked structure similar to collagen and can be used as a model for collagen; After combining with the gelatin molecules in a dark environment, the pyridinoline cross-linked structure in the gelatin is selectively destroyed by photosensitization of the pyridinine, suggesting that the photodynamic effect of the dioctin may be used to regulate the synthesis of collagen in collagen. The content of the pyridinoline cross-linking pattern tends to normalize, thereby achieving the purpose of treating fibrosis.
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Original research was done by Zhang Jucheng, Liu Wei, Yi Zhongzhou, Chen Rui, Li Ying, Min Yong
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