Tumor Angiogenesis Inhibitor Derived From Type Iv Collagen
Keywords
Neovascularization, Tumor Angiogenesis Inhibitory Factor, Endothelial Cells, Tumor
Abstract
Neovascularization is the basis for various physiological and pathological processes. In normal physiological processes such as embryogenesis and placental development, the formation of new blood vessels is crucial; however, the occurrence of some diseases, especially the growth, progression and metastasis of tumors, is also inseparable from the role of angiogenesis. With the proposal of “anti-tumor angiogenesis therapy”, angiogenesis stimulating factors and inhibitory factors that control the “switch” of angiogenesis have become a hot research topic. arresten, canstatin, tumstatin and hexastatin are endogenous angiogenesis inhibitory factors discovered in recent years. They are homologous to the non-collagen region nc1 of type IV collagen ¦Á chain and have similar structures and molecular weights. Existing studies have shown that they can Combined with integrin receptors on the surface of endothelial cells, it effectively inhibits the proliferation and migration of endothelial cells, reduces the microvessel density of tumor tissues, cuts off the nutrient and oxygen supply to tumors, thereby inhibiting tumor growth and metastasis. Research on its mechanism of action will contribute to the development of new drugs as tumor angiogenesis inhibitors.
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Original research was done by Wen Lei**, Song Naling**, He Xin, Zhao Qiren
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